PP2C alpha/PPM1A Antibody (4E11)

Novus Biologicals, part of Bio-Techne | Catalog # H00005494-M03

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Proximity Ligation Assay, Sandwich ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 4E11

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all PP2C alpha/PPM1A Antibodies »

Product Specifications

Immunogen

PPM1A (AAH26691, 1 a.a. ~ 382 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAVKKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNRLNPYKNDDTDSTSTDDMW

Specificity

PPM1A - protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform (4E11)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for PP2C alpha/PPM1A Antibody (4E11)

Immunocytochemistry/ Immunofluorescence: PP2C alpha/PPM1A Antibody (4E11) [H00005494-M03]

Immunocytochemistry/ Immunofluorescence: PP2C alpha/PPM1A Antibody (4E11) [H00005494-M03]

Immunocytochemistry/Immunofluorescence: PP2C alpha/PPM1A Antibody (4E11) [H00005494-M03] - Analysis of monoclonal antibody to PPM1A on HeLa cell. Antibody concentration 10 ug/ml
Immunohistochemistry-Paraffin: PP2C alpha/PPM1A Antibody (4E11) [H00005494-M03]

Immunohistochemistry-Paraffin: PP2C alpha/PPM1A Antibody (4E11) [H00005494-M03]

Immunohistochemistry-Paraffin: PP2C alpha/PPM1A Antibody (4E11) [H00005494-M03] - Analysis of monoclonal antibody to PPM1A on formalin-fixed paraffin-embedded human placenta. Antibody concentration 3 ug/ml
Proximity Ligation Assay: PP2C alpha/PPM1A Antibody (4E11) [H00005494-M03]

Proximity Ligation Assay: PP2C alpha/PPM1A Antibody (4E11) [H00005494-M03]

Proximity Ligation Assay: PP2C alpha/PPM1A Antibody (4E11) [H00005494-M03] - Analysis of protein-protein interactions between AKT1 and PPM1A. HeLa cells were stained with anti-AKT1 rabbit purified polyclonal 1:1200 and anti-PPM1A mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction c
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Applications for PP2C alpha/PPM1A Antibody (4E11)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: PP2C alpha/PPM1A

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]

Long Name

Protein Phosphatase 2C alpha

Alternate Names

MMPa-2, MPPa-1, Pp2c1, PPM1A

Entrez Gene IDs

5494 (Human)

Gene Symbol

PPM1A

UniProt

AAH26691 (Human)

Additional PP2C alpha/PPM1A Products

Product Documents for PP2C alpha/PPM1A Antibody (4E11)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PP2C alpha/PPM1A Antibody (4E11)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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