PRDM11 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-1525

Novus Biologicals, part of Bio-Techne
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NB100-1525
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all PRDM11 Antibodies »

Product Specifications

Immunogen

Peptide with sequence LSEGRVRSGLCGG corresponding to C-Terminus according to NP_064614.2.

Epitope

C Terminus

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for PRDM11 Antibody

Western Blot: PRDM11 Antibody [NB100-1525]

Western Blot: PRDM11 Antibody [NB100-1525]

Western Blot: PRDM11 Antibody [NB100-1525] - (2ug/ml) staining of A549 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry-Paraffin: PRDM11 Antibody [NB100-1525]

Immunohistochemistry-Paraffin: PRDM11 Antibody [NB100-1525]

Immunohistochemistry-Paraffin: PRDM11 Antibody [NB100-1525] - Staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for PRDM11 Antibody

Application
Recommended Usage

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Peptide ELISA

Detection limit 1:32000

Western Blot

2 - 3 ug/ml
Application Notes
WB: Approx. 50 kDa band observed in human lung carcinoma A549 lysates (calculated MW of 58 kDa band according to NP_064614.2).
IHC: Paraffin embedded Human Brain (Cortex).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PRDM11

The newly discovered family of PR domain genes is involved in tumorigenesis. Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein interacting zinc finger gene RIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation.

Alternate Names

PFM8PR domain-containing protein 11, PR domain containing 11, PR-domain containing protein 11

Entrez Gene IDs

56981 (Human)

Gene Symbol

PRDM11

Additional PRDM11 Products

Product Documents for PRDM11 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PRDM11 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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