PREB Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB120-3422

Novus Biologicals, part of Bio-Techne
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NB120-3422
NB120-3422-0.025ml
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Key Product Details

Species Reactivity

Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all PREB Antibodies »

Product Specifications

Immunogen

Recombinant mouse PREB.

Specificity

Detects recombinant mouse PREB (Prolactin Regulatory Element Binding protein).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PREB Antibody

Western Blot: PREB Antibody [NB120-3422]

Western Blot: PREB Antibody [NB120-3422]

Western Blot: PREB Antibody [NB120-3422] - Analysis of recombinant mouse PREB.

Applications for PREB Antibody

Application
Recommended Usage

Western Blot

1:500
Application Notes
WB: Detects an approx. 45 kDa protein representing recombinant mouse PREB.

Formulation, Preparation, and Storage

Purification

Ammonium sulfate precipitation

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PREB

Prolactin (PRL) expression in the pituitary is limited to specific cells. Pit-1 is a pituitary specific transcription factor that plays an important role in PRL expression, both in mature organism and during development. The PRL promoter contains numerous Pit-1 binding sites and these sites have been implicated in both basal level and kinase-mediated gene expression. The most proximal of these binding sites, termed 1P, has been shown to direct a response to numerous signals, such as cAMP and various G-proteins. A novel protein, termed PREB (prolactin regulatory element binding protein), has been recently identified that regulates PRL gene expression through the 1P site, though it contains no discernable DNA-binding motif. Recent studies suggest that PREB is encoded by a single-copy gene in both mice and humans and exhibits nuclear accumulation in pituitary cells. Evidence suggests that PREB is a novel transcription factor that assists in PRL expression whether alone, or in concert with Pit-1.

Long Name

Prolactin Regulatory Element Binding

Alternate Names

MGC3467, SEC12

Entrez Gene IDs

50907 (Mouse)

Gene Symbol

PREB

Additional PREB Products

Product Documents for PREB Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for PREB Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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