Progesterone R/NR3C3 Antibody (SPM566) - IHC-Prediluted
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-44917
![Immunohistochemistry-Paraffin: Progesterone R/NR3C3 Antibody (SPM566) - IHC-Prediluted [NBP2-44917]](https://resources.bio-techne.com/images/products/Progesterone-R-NR3C3-Antibody-SPM566-IHC-Prediluted-Immunohistochemistry-Paraffin-NBP2-44917-img0001.jpg "Immunohistochemistry-Paraffin: Progesterone R/NR3C3 Antibody (SPM566) - IHC-Prediluted [NBP2-44917]")
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Species Reactivity
Validated:
Human
Applications
Immunohistochemistry, Immunohistochemistry-Paraffin
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG1 kappa Clone # SPM566
Format
IHC-Prediluted
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Summary for Progesterone R/NR3C3 Antibody (SPM566) - IHC-Prediluted
Immunogen
Recombinant full-length human Progesterone R/NR3C3 protein (PGR) (Uniprot: P06401 )
Localization
Nuclear
Specificity
This monoclonal antibody is specific to progesterone receptor and shows minimal cross-reaction with other members of the family. Progesterone receptor is expressed as two major isoforms, PR-A (81kDa) and PR-B (116kDa). Expression of PgR has been suggested to reflect a intact estrogen regulatory machinery and therefore, predict better clinical response to endocrine therapy than ER alone. It is excellent for immunohistochemical staining of formalin/paraffin tissues.
Marker
Marker of Progestin Dependence
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1 kappa
Description
The prediluted antibody does not require any mixing, dilution, reconstitution, or titration; the antibody is ready-to-use and optimized for staining.
Scientific Data Images for Progesterone R/NR3C3 Antibody (SPM566) - IHC-Prediluted
Immunohistochemistry-Paraffin: Progesterone R/NR3C3 Antibody (SPM566) - IHC-Prediluted [NBP2-44917]
Immunohistochemistry-Paraffin: Progesterone R/NR3C3 Antibody (SPM566) - IHC-Prediluted [NBP2-44917] - Formalin-paraffin normal human breast carcinoma stained with Progesterone Receptor MAb (SPM566).Applications for Progesterone R/NR3C3 Antibody (SPM566) - IHC-Prediluted
Application
Recommended Usage
Immunohistochemistry
Optimal dilutions of this antibody should be experimentally determined.
Immunohistochemistry-Paraffin
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Immunohistochemistry (Formalin-fixed): 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes.
Optimal dilution for a specific application should be determined.
Optimal dilution for a specific application should be determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
10 mM PBS with 0.05% BSA
Format
IHC-Prediluted
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C.
Background: Progesterone R/NR3C3
Long Name
Progesterone Receptor
Alternate Names
NR3C3, PGR, ProgesteroneR
Gene Symbol
PGR
Additional Progesterone R/NR3C3 Products
Product Documents for Progesterone R/NR3C3 Antibody (SPM566) - IHC-Prediluted
Product Specific Notices for Progesterone R/NR3C3 Antibody (SPM566) - IHC-Prediluted
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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