Prokineticin R1/PROKR1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-15201

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

LYOPH mg/ml

View all Prokineticin R1/PROKR1 Antibodies »

Product Specifications

Immunogen

Synthetic peptide derived from N terminal region of human prokineticin receptor 1.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

45 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Prokineticin R1/PROKR1 Antibody

Immunohistochemistry: Prokineticin R1/PROKR1 Antibody [NBP2-15201]

Immunohistochemistry: Prokineticin R1/PROKR1 Antibody [NBP2-15201]

Immunohistochemistry: Prokineticin R1/PROKR1 Antibody [NBP2-15201] - Staining of human umbilical cord and placental villi

Applications for Prokineticin R1/PROKR1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:200

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Lyophilized powder, reconstituted in distilled water.

Formulation

0.1M Tris , 0.1M Glycine and 2% Sucrose

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Prokineticin R1/PROKR1

PKR (protein kinase, activatable by RNA) is a double-stranded (ds) RNA-activated protein kinase that plays a key role in the innate immunity response to viral infection in higher eukaryotes (reviewed in Langland et al, 2006). PKR contains an N-terminal dsRNA-binding domain that consists of consensus dsRNA-binding motifs and a C-terminal kinase domain containing conserved motifs for protein kinase activity. DsRNA is a well characterized danger signal that the cell uses recognize the presence of viral infection. PKR binds to dsRNA molecules during viral infection and triggers antiviral innate defense mechanisms including the induction of type I interferons and downregulation of gene expression. One of the most well characterized substrates of activated PKR is the eukaryotic tranlation initiation facter, eIF2. PKR phosphorylates eIF2 during virus infection, which ultimately leads to an inhibition in protein synthesis and block in viral replication. The key role played by PKR in innate responses to viral infections is underscored by the large number of DNA and RNA viruses, whose hosts range from insects to humans, that code for PKR inhibitors. PKR is also known as PRKR, EIF2AK1, and EIF2AK2. Recognizes PKR; human PKR is 942 amino acid protein.

Long Name

Prokineticin Receptor 1

Alternate Names

GPR73, GPR73a, PKR1, ProkineticinR1, PROKR1, ZAQ

Gene Symbol

PROKR1

UniProt

Q8TCW9

Additional Prokineticin R1/PROKR1 Products

Product Documents for Prokineticin R1/PROKR1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Prokineticin R1/PROKR1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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