Proprotein Convertase 1/PCSK1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-19714

Novus Biologicals, part of Bio-Techne
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NBP2-19714
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Predicted:

Bovine (98%), Porcine (100%), Rat (100%), Zebrafish (93%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Proprotein Convertase 1/PCSK1 Antibodies »

Product Summary for Proprotein Convertase 1/PCSK1 Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human Proprotein Convertase 1/PCSK1. The exact sequence is proprietary.

Localization

Cytoplasmic vesicle; secretory vesicle

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

84 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Proprotein Convertase 1/PCSK1 Antibody

Western Blot: Proprotein Convertase 1/PCSK1 Antibody [NBP2-19714]

Western Blot: Proprotein Convertase 1/PCSK1 Antibody [NBP2-19714]

Western Blot: PC1/3 Antibody [NBP2-19714] - Sample (30 ug of whole cell lysate) A: HCT116 7. 5% SDS PAGE gel, diluted at 1:500.
Immunohistochemistry-Paraffin: Proprotein Convertase 1/PCSK1 Antibody [NBP2-19714]

Immunohistochemistry-Paraffin: Proprotein Convertase 1/PCSK1 Antibody [NBP2-19714]

Immunohistochemistry-Paraffin: PC1/3 Antibody [NBP2-19714] - Mouse intestine. PC1/3 antibody dilution: 1:500.
Immunohistochemistry-Paraffin: Proprotein Convertase 1/PCSK1 Antibody [NBP2-19714]

Immunohistochemistry-Paraffin: Proprotein Convertase 1/PCSK1 Antibody [NBP2-19714]

Immunohistochemistry-Paraffin: PC1/3 Antibody [NBP2-19714] - Analysis of paraffin-embedded Cal27 xenograft, using antibody at 1:500 dilution.

Applications for Proprotein Convertase 1/PCSK1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:3000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

0.1M Tris (pH 7), 0.1M Glycine, 20% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Proprotein Convertase 1/PCSK1

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known. [provided by RefSeq]

Alternate Names

NEC1, PCSK1

Gene Symbol

PCSK1

UniProt

P29120

Additional Proprotein Convertase 1/PCSK1 Products

Product Documents for Proprotein Convertase 1/PCSK1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Proprotein Convertase 1/PCSK1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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