Prostaglandin I2 Synthase Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-85359

Novus Biologicals, part of Bio-Techne
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NBP1-85359
NBP1-85359-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Prostaglandin I2 Synthase Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: LTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQ

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (89%), Rat (85%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Prostaglandin I2 Synthase Antibody

Western Blot: Prostaglandin I2 Synthase Antibody [NBP1-85359]

Western Blot: Prostaglandin I2 Synthase Antibody [NBP1-85359]

Western Blot: Prostaglandin I2 Synthase Antibody [NBP1-85359] - Analysis in human cell line U-2197.
Immunohistochemistry-Paraffin: Prostaglandin I2 Synthase Antibody [NBP1-85359]

Immunohistochemistry-Paraffin: Prostaglandin I2 Synthase Antibody [NBP1-85359]

Immunohistochemistry-Paraffin: Prostaglandin I2 Synthase Antibody [NBP1-85359] - Staining of human duodenum shows strong cytoplasmic positivity in glandular cells.

Applications for Prostaglandin I2 Synthase Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Prostaglandin I2 Synthase

PTGIS encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.

Alternate Names

CYP8, CYP8A1, PGIS, Prostacyclin Synthase, PTGI

Gene Symbol

PTGIS

Additional Prostaglandin I2 Synthase Products

Product Documents for Prostaglandin I2 Synthase Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Prostaglandin I2 Synthase Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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