Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signaling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.

Long Name

Proteasome subunit alpha type-5

Alternate Names

PSMA5

Gene Symbol

PSMA5

Additional Proteasome 20S alpha 5 Products

Product Documents for Proteasome 20S alpha 5 Antibody (AH1.1) [Janelia Fluor® 549]

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for Proteasome 20S alpha 5 Antibody (AH1.1) [Janelia Fluor® 549]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

Spectra Viewer
Flow Cytometry

Proteasome 20S alpha 5 Antibody (AH1.1) [Janelia Fluor® 549]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-76657JF549

Key Product Details

Species Reactivity

Validated:

Applications

Label

Antibody Source

Concentration

View all Proteasome 20S alpha 5 Antibodies »

Product Summary for Proteasome 20S alpha 5 Antibody (AH1.1) [Janelia Fluor® 549]

Immunogen

Clonality

Host

Isotype

Applications for Proteasome 20S alpha 5 Antibody (AH1.1) [Janelia Fluor® 549]

Flow Cytometry

Immunohistochemistry

Immunoprecipitation

Western Blot

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: Proteasome 20S alpha 5