PrPC Antibody (S03-2E2)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19967

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19967-100ul
NBP3-19967-50ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S03-2E2

Concentration

0.3 mg/ml

View all PrPC Antibodies »

Product Specifications

Immunogen

A synthetic peptide of human PrPC (Uniprot # P04156)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

28 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for PrPC Antibody (S03-2E2)

Western Blot: PrPC Antibody (S03-2E2) [NBP3-19967]

Western Blot: PrPC Antibody (S03-2E2) [NBP3-19967]

Western Blot: PrPC Antibody (S03-2E2) [NBP3-19967] - Western blot detection of PrPC in Rat Brain and Mouse Brain lysates using NBP3-19967 (1:1000 diluted). Predicted band size: 28kDa. Observed band size: 28kDa.
Immunohistochemistry-Paraffin: PrPC Antibody (S03-2E2) [NBP3-19967]

Immunohistochemistry-Paraffin: PrPC Antibody (S03-2E2) [NBP3-19967]

Immunohistochemistry-Paraffin: PrPC Antibody (S03-2E2) [NBP3-19967] - Immunohistochemistry of Prion protein in paraffin-embedded Human breast cancer tissue using NBP3-19967 at dilution 1/20

Applications for PrPC Antibody (S03-2E2)

Application
Recommended Usage

Immunohistochemistry

1/20

Western Blot

1/1000-1/5000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PrPC

Prion diseases are transmissible neurodegenerative disorders which affect a range of mammalian species. In humans they can be inherited and sporadic as well as acquired by exposure to human prions. Prions appear to be composed principally of a conformational isomer of host-encoded prion protein and propagate by recruitment of cellular prion protein (1). The function of the cellular prion protein (PrP) is still poorly understood. It has been proposed that one unprecedented role for PrP is against Bax-mediated neuronal apoptosis. It has been shown that PrP potently inhibits Bax-induced cell death in human primary neurons (2). An impaired synaptic inhibition may be involved in the epileptiform activity seen in Creutzfeldt-Jakob and other neurodegenerative diseases and it is believed that loss of function of PrP may contribute to the early synaptic loss and neuronal degeneration seen in these diseases (3).

Alternate Names

CD230, CJD, fatal familial insomnia), GSS, prion protein, prion protein (p27-30), prion protein PrP, prion-related protein, PRIPMGC26679

Gene Symbol

PRNP

Additional PrPC Products

Product Documents for PrPC Antibody (S03-2E2)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PrPC Antibody (S03-2E2)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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