PSD93 Antibody (0G4O6)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-15849

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-15849-100ul
NBP3-15849-20ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 0G4O6

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PSD93 Antibodies »

Product Summary for PSD93 Antibody (0G4O6)

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 600-700 of human PSD93 (Q15700). RRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISE

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PSD93 Antibody (0G4O6)

Western Blot: PSD93 Antibody (0G4O6) [NBP3-15849]

Western Blot: PSD93 Antibody (0G4O6) [NBP3-15849]

Western Blot: PSD93 Antibody (0G4O6) [NBP3-15849] - Western blot analysis of extracts of various cell lines, using PSD93 Rabbit mAb (NBP3-15849) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Immunocytochemistry/ Immunofluorescence: PSD93 Antibody (0G4O6) [NBP3-15849]

Immunocytochemistry/ Immunofluorescence: PSD93 Antibody (0G4O6) [NBP3-15849]

Immunocytochemistry/Immunofluorescence: PSD93 Antibody (0G4O6) [NBP3-15849] - Immunofluorescence analysis of mouse brain cells using PSD93 Rabbit mAb (NBP3-15849) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

Applications for PSD93 Antibody (0G4O6)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50 - 1:200

Western Blot

1:500 - 1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 0.05% BSA, 50% glycerol, pH7.3

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PSD93

Post Synaptic Density 93 (PSD 93), also known as chapsyn-110, is one of a family of plasma membrane-associated proteins found in synaptic junctions. PSD 93 is unique among family members in its expression in Purkinje neuron cell bodies and dendrites. PSD 93 has three ~90 amino acid repeats called PDZ domains, a single interior SH3 domain, and a carboxyl-terminal guanylate kinase homology (GuK) domain that is enzymatically inactive. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticity.PSD 93 is believed to participate in the clustering of certain proteins, including N-methyl-D-aspartate (NMDA) receptors and shaker-type potassium channels at the synaptic membrane. There are two principal modes of interaction between PSD 93 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with PSD 93 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD 93 in vitro through a pseudo-homotypic PDZ-PDZ interaction.

Alternate Names

Chapsyn-110, discs, large homolog 2 (Drosophila), discs, large homolog 2, chapsyn-110, discs, large homolog 2, chapsyn-110 (Drosophila), disks large homolog 2, DKFZp781D1854, DKFZp781E0954, FLJ37266, MGC131811, Postsynaptic density protein PSD-93, PSD-93, PSD93,110kDa

Gene Symbol

DLG2

Additional PSD93 Products

Product Documents for PSD93 Antibody (0G4O6)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PSD93 Antibody (0G4O6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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