PTH Antibody (PTH/1717R) - N-terminal - Azide and BSA Free
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-54474
Recombinant Monoclonal Antibody.
![Immunohistochemistry-Paraffin: PTH Antibody (PTH/1717R) - N-terminal - Azide and BSA Free [NBP2-54474]](https://resources.bio-techne.com/images/products/PTH-Antibody-PTH-1717R-Immunohistochemistry-Paraffin-NBP2-54474-img0001.jpg "Immunohistochemistry-Paraffin: PTH Antibody (PTH/1717R) - N-terminal - Azide and BSA Free [NBP2-54474]")
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Immunohistochemistry, Immunohistochemistry-Paraffin
Label
Unconjugated
Antibody Source
Recombinant Monoclonal Rabbit IgG Clone # PTH/1717R
Format
Azide and BSA Free
Concentration
1 mg/ml
Product Specifications
Immunogen
A synthetic peptide around aa 1-34 of human mature-PTH-polypeptide (exact sequence is proprietary) (Uniprot: P01270)
Reactivity Notes
Predicted to react with Mouse. Rat. Rabbit. Bovine. Canine. Porcine. Deer. Orangutan.
Localization
Cytoplasmic and Secreted
Specificity
Epitope of this monoclonal antibody maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
Clonality
Monoclonal
Host
Rabbit
Isotype
IgG
Theoretical MW
9 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Description
1.0 mg/ml of antibody purified by Protein A. Prepared in 10mM PBS WITHOUT BSA & azide. Also available at 200 ug/ml WITH BSA & azide (NBP2-53170).
Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C.
Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C.
Scientific Data Images for PTH Antibody (PTH/1717R) - N-terminal - Azide and BSA Free
Immunohistochemistry-Paraffin: PTH Antibody (PTH/1717R) - N-terminal - Azide and BSA Free [NBP2-54474]
Immunohistochemistry-Paraffin: PTH Antibody (PTH/1717R) [NBP2-54474] - Formalin-fixed, paraffin-embedded human Parathyroid stained with PTH Recombinant Rabbit Monoclonal Antibody (PTH/1717R).Applications for PTH Antibody (PTH/1717R) - N-terminal - Azide and BSA Free
Application
Recommended Usage
Immunohistochemistry
Optimal dilutions of this antibody should be experimentally determined.
Immunohistochemistry-Paraffin
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Immunohistochemistry (Formalin-fixed): 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes.
Optimal dilution for a specific application should be determined.
Optimal dilution for a specific application should be determined.
Formulation, Preparation, and Storage
Purification
Protein A purified
Formulation
10 mM PBS
Format
Azide and BSA Free
Preservative
No Preservative
Concentration
1 mg/ml
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at -20 to -80C. Avoid freeze-thaw cycles.
Background: PTH
Long Name
Parathyroid Hormone
Alternate Names
Parathormone, Parathyrin
Gene Symbol
PTH
Additional PTH Products
Product Documents for PTH Antibody (PTH/1717R) - N-terminal - Azide and BSA Free
Product Specific Notices for PTH Antibody (PTH/1717R) - N-terminal - Azide and BSA Free
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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