PTH Antibody (SPM604) [Janelia Fluor® 549] - N-terminal
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-54434JF549
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Species Reactivity
Validated:
Human
Applications
Immunohistochemistry, Immunohistochemistry-Paraffin
Label
Janelia Fluor 549
Antibody Source
Monoclonal Mouse IgG2b Kappa Clone # SPM604
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Summary for PTH Antibody (SPM604) [Janelia Fluor® 549] - N-terminal
Immunogen
A synthetic peptide around aa 1-34 of human mature-PTH-polypeptide (exact sequence is proprietary) (Uniprot: P01270)
Reactivity Notes
Predicted to react with Mouse. Rat. Rabbit. Bovine. Canine. Porcine. Deer. Orangutan.
Localization
Cytoplasmic and Secreted
Specificity
Epitope of this monoclonal antibody maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2b Kappa
Applications for PTH Antibody (SPM604) [Janelia Fluor® 549] - N-terminal
Application
Recommended Usage
Immunohistochemistry
Optimal dilutions of this antibody should be experimentally determined.
Immunohistochemistry-Paraffin
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: PTH
Long Name
Parathyroid Hormone
Alternate Names
Parathormone, Parathyrin
Gene Symbol
PTH
Additional PTH Products
Product Documents for PTH Antibody (SPM604) [Janelia Fluor® 549] - N-terminal
Product Specific Notices for PTH Antibody (SPM604) [Janelia Fluor® 549] - N-terminal
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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