PTP rho/PTPRT Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-75300

Novus Biologicals, part of Bio-Techne
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NB100-75300
NB100-75300-0.025mg
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Key Product Details

Species Reactivity

Human, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Chicken

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PTP rho/PTPRT Antibodies »

Product Specifications

Immunogen

The immunogen for this antibody was a sequence from 383a.a. to 484a.a. from PTP rho(a 1444a.a. long protein)

Reactivity Notes

This antibody is reactive against Human, rat.

Localization

Membrane; single-pass type I membrane protein.

Specificity

PTP rho

Clonality

Polyclonal

Host

Chicken

Scientific Data Images for PTP rho/PTPRT Antibody

Western Blot: PTP rho/PTPRT Antibody [NB100-75300]

Western Blot: PTP rho/PTPRT Antibody [NB100-75300]

Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. (anti-PTPRT)

Applications for PTP rho/PTPRT Antibody

Application
Recommended Usage

Western Blot

1:200 - 1:500
Application Notes
Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000. Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2)

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PTP rho/PTPRT

PTP rho is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP rho is a large protein that possesses a PTP domain at the C-terminus, and multiple noncatalytic domains, which include a domain with similarity to the band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. PTP rho interacts with, and dephosphorylates, Fas receptor, as well as I-kappa B-alpha through the PDZ domains, which suggests that it may have a role in Fas-mediated programmed cell death. PTP rho also interacts with GTPase-activating protein, and thus may function as a regulator of the Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. May be involved in both signal transduction and cellular adhesion in the CNS.

Long Name

Protein Tyrosine Phosphatase Receptor-type T

Alternate Names

PTPRT, RPTP-rho

Entrez Gene IDs

11122 (Human); 362263 (Rat)

Gene Symbol

PTPRT

UniProt

O14522

Additional PTP rho/PTPRT Products

Product Documents for PTP rho/PTPRT Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for PTP rho/PTPRT Antibody

Chicken products cannot be exported to Canada.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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