RAG2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # H00005897-B01P

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Mouse IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all RAG2 Antibodies »

Product Specifications

Immunogen

RAG2 (NP_000527.1, 1 a.a. - 527 a.a.) full-length human protein. MSLQMVTVSNNIALIQPGFSLMNFDGQVFFFGQKGWPKRSCPTGVFHLDVKHNHVKLKPTIFSKDSCYLPPLRYPATCTFKGSLESEKHQYIIHGGKTPNNEVSDKIYVMSIVCKNNKKVTFRCTEKDLVGDVPEARYGHSINVVYSRGKSMGALFGGRSYMPSTHRTTEKWNSVADCLPCVFLVDFEFGCATSYILPELQDGLSFHVSIAKNDTIYILGGHSLANNIRPANLYRIRVDLPLGSPAVNCTVLPGGISVSSAILTQTNNDEFVIVGGYQLENQKRMICNIISLEDNKIEIREMETPDWTPDIKHSKIWFGSNTGNGTVFLGIPGDNKQVVSEGFYFYMLKCAEDDTNEEQTTFTNSQTSTEDPGDSTPFEDSEEFCFSAEANSFDGDDEFDTYNEDDEEDESETGYWITCCPTCDVDINTWVPFYSTELNKPAMIYCSHGDGHWVHAQCMDLAERTLIHLSAGSNKYYCNEHVEIARALHTPQRVLPLKKPPMKSLRKKGSGKILTPAKKSFLRRLFD

Specificity

Reacts with recombination activating gene 2.

Clonality

Polyclonal

Host

Mouse

Isotype

IgG

Description

Quality control test: Antibody reactive against mammalian transfected lysate.

Scientific Data Images for RAG2 Antibody

Western Blot: RAG2 Antibody [H00005897-B01P]

Western Blot: RAG2 Antibody [H00005897-B01P]

Western Blot: RAG2 Antibody [H00005897-B01P] - Analysis of RAG2 expression in transfected 293T cell line by RAG2 polyclonal antibody. Lane 1: RAG2 transfected lysate(57.97 KDa). Lane 2: Non-transfected lysate.
Immunocytochemistry/ Immunofluorescence: RAG2 Antibody [H00005897-B01P]

Immunocytochemistry/ Immunofluorescence: RAG2 Antibody [H00005897-B01P]

Immunocytochemistry/Immunofluorescence: RAG2 Antibody [H00005897-B01P] - Analysis of purified antibody to RAG2 on HeLa cell. (antibody concentration 10 ug/ml)

Applications for RAG2 Antibody

Application
Recommended Usage

Western Blot

1:500
Application Notes
This antibody is reactive against transfected lysate in WB, IF and as a detection antibody in ELISA.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: RAG2

This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq]

Alternate Names

RAG-2, recombination activating gene 2, V(D)J recombination-activating protein 2

Entrez Gene IDs

5897 (Human)

Gene Symbol

RAG2

UniProt

NP_000527.1 (Human)

Additional RAG2 Products

Product Documents for RAG2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for RAG2 Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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