RAGEF2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-06550

Novus Biologicals, part of Bio-Techne
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Human

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all RAGEF2 Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 625 and 675 of human PDZ domain containing guanine nucleotide exchange factor (GEF) 2 using the numbering given in entry NP_057424.2 (GeneID 51735).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for RAGEF2 Antibody

Western Blot: RAGEF2 Antibody [NBP1-06550]

Western Blot: RAGEF2 Antibody [NBP1-06550]

Western Blot: RAGEF2 Antibody [NBP1-06550] - Whole cell lysate from HeLa cells. PDZ-GEF2 was also immunoprecipitated by rabbit anti-PDZ-GEF2 antibody NBP1-06550.

Applications for RAGEF2 Antibody

Application
Recommended Usage

Immunoprecipitation

1:10-1:500

Western Blot

1:100-1:2000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: RAGEF2

PDZ-GEF2 is a guanine nucleotide exchange factor (GEF) for Rap GTPases. It contains one PDZ-signaling domain, a Ras-association (RA) domain, and a region related to a cyclic nucleotide binding domain (RCBD). PDZ-GEF1 functions to catalyze the exchange of GDP for GTP and activate Rap1A, Rap1B, and Rap2B GTPase activity. PDZ-GEF2 has been shown to activate Rap1A and Rap1B to promote the maturation of cell-cell adherens junctions. Alternative names for PDZ-GEF2 include Rap guanine nucleotide exchange factor 6, PDZ domain-containing guanine nucleotide exchange factor 2, RAPGEF6, RA-GEF-2, RAGEF2, PDZGEF2, and KIA001LB.

Alternate Names

DKFZp667N084, DKFZp686I15116, KIA001LB, PDZ domain-containing guanine nucleotide exchange factor 2, PDZ domain-containing guanine nucleotide exchange factor I, PDZ-GEF2RA-GEF-2PDZGEF2PDZ domain containing guanine nucleotide exchange factor (GEF) 2, RAGEF2, Rap guanine nucleotide exchange factor (GEF) 6, rap guanine nucleotide exchange factor 6

Entrez Gene IDs

51735 (Human)

Gene Symbol

RAPGEF6

UniProt

NP_057424.2 (Human)

Additional RAGEF2 Products

Product Documents for RAGEF2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for RAGEF2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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