Ran Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-1442

Novus Biologicals, part of Bio-Techne
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NB100-1442
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Predicted:

Bovine (100%), Canine (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all Ran Antibodies »

Product Specifications

Immunogen

Peptide with sequence AAQGEPQVQFKLV-C corresponding to N-Terminus according to NP_006316.1.

Localization

Nuclear

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Ran Antibody

Western Blot: Ran Antibody [NB100-1442]

Western Blot: Ran Antibody [NB100-1442]

Western Blot: Ran Antibody [NB100-1442] - Staining of A431 with antibody at 0.5 ug/mL (35 ug protein in RIPA buffer). Detected by chemiluminescence.
Immunohistochemistry-Paraffin: Ran Antibody [NB100-1442]

Immunohistochemistry-Paraffin: Ran Antibody [NB100-1442]

Immunohistochemistry-Paraffin: Ran Antibody [NB100-1442] - Negative Control showing staining of paraffin embedded Human Tonsil, with no primary antibody.
Immunohistochemistry-Paraffin: Ran Antibody [NB100-1442]

Immunohistochemistry-Paraffin: Ran Antibody [NB100-1442]

Immunohistochemistry-Paraffin: Ran Antibody [NB100-1442] - Staining of paraffin embedded Human Tonsil with antibody at 3 ug/mL. Heat induced antigen retrieval with citrate buffer pH 6, HRP-staining.

Applications for Ran Antibody

Application
Recommended Usage

Immunohistochemistry

3 ug/mL

Immunohistochemistry-Paraffin

3 ug/mL

Peptide ELISA

Detection limit 1:32000

Western Blot

0.3 - 1 ug/mL

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Ran

Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of Ran-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.

Alternate Names

Androgen receptor-associated protein 24, ARA24Gsp1, GTPase Ran, GTP-binding nuclear protein Ran, guanosine triphosphatase Ran, member RAS oncogene family, OK/SW-cl.81, RAN, member RAS oncogene family, RanGTPase, Ras-like protein TC4, Ras-related nuclear protein, TC4

Entrez Gene IDs

5901 (Human); 19384 (Mouse); 84509 (Rat)

Gene Symbol

RAN

UniProt

NP_006316. (Human)

Additional Ran Products

Product Documents for Ran Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Ran Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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