RAR alpha/NR1B1 Antibody (2C3)

Novus Biologicals, part of Bio-Techne | Catalog # H00005914-M09

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 2C3

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all RAR alpha/NR1B1 Antibodies »

Product Specifications

Immunogen

RARA (NP_000955, 315 a.a. ~ 424 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. QLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLS

Specificity

RARA - retinoic acid receptor, alpha (2C3)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for RAR alpha/NR1B1 Antibody (2C3)

Western Blot: RAR alpha/NR1B1 Antibody (2C3) [H00005914-M09]

Western Blot: RAR alpha/NR1B1 Antibody (2C3) [H00005914-M09]

Western Blot: RAR alpha/NR1B1 Antibody (2C3) [H00005914-M09] - Analysis of RARA expression in Hela S3 NE (Cat # L013V3).
Immunocytochemistry/ Immunofluorescence: RAR alpha/NR1B1 Antibody (2C3) [H00005914-M09]

Immunocytochemistry/ Immunofluorescence: RAR alpha/NR1B1 Antibody (2C3) [H00005914-M09]

Immunocytochemistry/Immunofluorescence: RAR alpha/NR1B1 Antibody (2C3) [H00005914-M09] - Analysis of monoclonal antibody to RARA on HeLa cell. Antibody concentration 10 ug/ml

Applications for RAR alpha/NR1B1 Antibody (2C3)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for ELISA.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: RAR alpha/NR1B1

Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR; see MIM 180245), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1 (MIM 600849), SMRT (NCOR2; MIM 600848), and histone deacetylase (see MIM 601241). When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases (see MIM 603053), and the basic transcription machinery. Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (MIM 102578) (Vitoux et al., 2007 [PubMed 17468032]).[supplied by OMIM]

Long Name

Retinoic Acid Receptor, alpha

Alternate Names

NR1B1, RARA

Gene Symbol

RARA

Additional RAR alpha/NR1B1 Products

Product Documents for RAR alpha/NR1B1 Antibody (2C3)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for RAR alpha/NR1B1 Antibody (2C3)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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