RAR gamma/NR1B3 Antibody (SR1891)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21974

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21974-100ul
NBP3-21974-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1891

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all RAR gamma/NR1B3 Antibodies »

Product Summary for RAR gamma/NR1B3 Antibody (SR1891)

Immunogen

A synthesized peptide derived from human RAR gamma/NR1B3 (Uniprot #: P13631)

Specificity

Detects endogenous levels of total RAR gamma/NR1B3

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

50 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for RAR gamma/NR1B3 Antibody (SR1891)

Western Blot: RAR gamma/NR1B3 Antibody (SR1891) [NBP3-21974] -

Western Blot: RAR gamma/NR1B3 Antibody (SR1891) [NBP3-21974] - Western blot analysis using NBP3-21974 in HeLa cell lysate.

Applications for RAR gamma/NR1B3 Antibody (SR1891)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: RAR gamma/NR1B3

Retinoids can reverse various premalignant lesions as well as prevent some second primary tumors. The effects of retinoids are regulated by retinoic acid receptors (RAR) and retinoid X receptors, which act as ligand-activated transcription factors. Ligand-dependent transcriptional activation of RARs is a multistep process that ends with the formation of a multimeric co-activator complex on regulated promoters. Retinoic acid receptor gamma has been shown to be the most important retinoid receptor for regulation of retinoic acid turnover rate and retinoic acid induced growth inhibition. While RAR mRNA levels may be useful biomarkers for various diseases, RAR gamma expression is decreased in Barrett's tissues compared with normal tissue.

Long Name

Retinoic Acid Receptor, gamma

Alternate Names

NR1B3, RARC, RARG

Gene Symbol

RARG

Additional RAR gamma/NR1B3 Products

Product Documents for RAR gamma/NR1B3 Antibody (SR1891)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for RAR gamma/NR1B3 Antibody (SR1891)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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