Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # RET/2663

Concentration

0.2 mg/ml

View all Ret Antibodies »

Product Specifications

Immunogen

Recombinant fragment (around aa 702-848) of human Ret protein (exact sequence is proprietary) (Uniprot: P07949)

Localization

Cytoplasmic, Cell Surface, Nuclear

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Description

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0 mg/ml. (NBP2-79896)

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C.

Scientific Data Images for Ret Antibody (RET/2663)

Immunohistochemistry-Paraffin: Ret Antibody (RET/2663) [NBP2-79761]

Immunohistochemistry-Paraffin: Ret Antibody (RET/2663) [NBP2-79761]

Immunohistochemistry-Paraffin: Ret Antibody (RET/2663) [NBP2-79761] - Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Ret Antibody (RET/2663).
Immunohistochemistry-Paraffin: Ret Antibody (RET/2663) [NBP2-79761]

Immunohistochemistry-Paraffin: Ret Antibody (RET/2663) [NBP2-79761]

Immunohistochemistry-Paraffin: Ret Antibody (RET/2663) [NBP2-79761] - Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Ret Antibody (RET/2663).
Protein Array: Ret Antibody (RET/2663) [NBP2-79761]

Protein Array: Ret Antibody (RET/2663) [NBP2-79761]

Protein Array: Ret Antibody (RET/2663) [NBP2-79761] - Analysis of Protein Array containing more than 19,000 full-length human proteins using Ret Antibody (RET/2663). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5

Applications for Ret Antibody (RET/2663)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Protein Array

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
ELISA: For coating, order Ab without BSA.
Optimal dilution for a specific application should be determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Ret

Ret, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.

Long Name

Proto-oncogene Tyrosine-protein Kinase Receptor Ret

Alternate Names

CDHF12MTC1, CDHR16, EC 2.7.10, Hirschsprung disease 1, Hirschsprung disease), MEN2A, MEN2B, multiple endocrine neoplasia and medullary thyroid carcinoma 1, ret proto-oncogene, RET transforming sequence

Gene Symbol

RET

UniProt

P07949

Additional Ret Products

Product Documents for Ret Antibody (RET/2663)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Ret Antibody (RET/2663)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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