RGS18 Antibody (SR1473)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-22111

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-22111-100ul
NBP3-22111-50ul
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1473

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all RGS18 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human RGS18 (Uniprot #: Q9NS28)

Specificity

Detects endogenous levels of total RGS18

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

28 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for RGS18 Antibody (SR1473)

Western Blot: RGS18 Antibody (SR1473) [NBP3-22111] -

Western Blot: RGS18 Antibody (SR1473) [NBP3-22111] - Western blot analysis using NBP3-22111 in Human PBMC lysate.

Applications for RGS18 Antibody (SR1473)

Application
Recommended Usage

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: RGS18

Regulators of G-protein signaling (RGSs) are a protein family that can act as GTPase-activating proteins for G(alphai)- and G(alphaq)-class proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. One of these proteins, RGS18, is a 235 amino acid protein that is closely related to RGS5 (46% identity) and approximately 30-40% identity to other RGS proteins. This protein is expressed in platelet, leukocyte, and megakaryocyte cell lines. Engagement of TLR3 or TLR4 on monocyte-derived DCs potently down-regulates RGS18 and RGS14 without modifying other RGS proteins. A similar pattern of RGS protein expression occurs in immature bone marrow-derived mouse DCs stimulated to mature via TLR4 signaling. The changes in RGS18 and RGS1 expression are likely important for DC function.

Alternate Names

regulator of G-protein signaling 18, regulator of G-protein signalling 13, RGS13regulator of G-protein signalling 18

Gene Symbol

RGS18

Additional RGS18 Products

Product Documents for RGS18 Antibody (SR1473)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for RGS18 Antibody (SR1473)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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