RGS18 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-24417

Novus Biologicals, part of Bio-Techne
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NBP2-24417
NBP2-24417SS
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Mouse

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Western Blot

Cited:

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all RGS18 Antibodies »

Product Specifications

Immunogen

Within the range of amino acids 30-62 of human RGS18 protein were used as the immunogen.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 17576169).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for RGS18 Antibody

Western Blot: RGS18 Antibody [NBP2-24417]

Western Blot: RGS18 Antibody [NBP2-24417]

Western Blot: RGS18 Antibody [NBP2-24417] - Western blot analysis of RGS18 in 1) transfected 293T cells and 2) untransfected 293T cells using NBP2-24417 at 1:500.

Applications for RGS18 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1: 100

Western Blot

1:250-1: 1000

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

0.1 ml crude whole Rabbit sera with 50% Glycerol

Preservative

0.025% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: RGS18

Regulators of G-protein signaling (RGSs) are a protein family that can act as GTPase-activating proteins for G(alphai)- and G(alphaq)-class proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. One of these proteins, RGS18, is a 235 amino acid protein that is closely related to RGS5 (46% identity) and approximately 30-40% identity to other RGS proteins. This protein is expressed in platelet, leukocyte, and megakaryocyte cell lines. Engagement of TLR3 or TLR4 on monocyte-derived DCs potently down-regulates RGS18 and RGS14 without modifying other RGS proteins. A similar pattern of RGS protein expression occurs in immature bone marrow-derived mouse DCs stimulated to mature via TLR4 signaling. The changes in RGS18 and RGS1 expression are likely important for DC function.

Alternate Names

regulator of G-protein signaling 18, regulator of G-protein signalling 13, RGS13regulator of G-protein signalling 18

Gene Symbol

RGS18

UniProt

Q9NS28 (Human)

Additional RGS18 Products

Product Documents for RGS18 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for RGS18 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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