RIN1 Antibody (27G2)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-66642

Novus Biologicals, part of Bio-Techne
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NBP2-66642
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 27G2

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all RIN1 Antibodies »

Product Specifications

Immunogen

Hybridoma produced by the fusion of splenocytes from mice immunized with full-length recombinant human Rin protein and mouse myeloma cells.

Specificity

Does not cross-react with Rit protein.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Scientific Data Images for RIN1 Antibody (27G2)

Western Blot: RIN1 Antibody (27G2) [NBP2-66642]

Western Blot: RIN1 Antibody (27G2) [NBP2-66642]

Western Blot: RIN1 Antibody (27G2) [NBP2-66642] - Western blot analysis using Rin antibody (Cat. No. NBP2-66642) on 293 cells expressing HA-tagged Rit (1) and HA-tagged Rin (2).

Applications for RIN1 Antibody (27G2)

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
.

Formulation, Preparation, and Storage

Purification

Ammonium sulfate precipitation

Formulation

20 mM sodium phosphate, 150 mM sodium chloride, 50% glycerol (pH 7.5)

Preservative

3mM Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: RIN1

Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64% amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100% conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.

Alternate Names

Ras and Rab interactor 1, ras inhibitor 1, Ras inhibitor JC99, ras inhibitor RIN1, Ras interaction/interference protein 1

Gene Symbol

RIN1

UniProt

Q13671 (Human)

Additional RIN1 Products

Product Documents for RIN1 Antibody (27G2)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for RIN1 Antibody (27G2)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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