RNA polymerase I termination factor Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38740

Novus Biologicals, part of Bio-Techne
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NBP2-38740
NBP2-38740-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all RNA polymerase I termination factor Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: VKRARVSGDDFSVPSKNSESTLFDSVEGDGAMMEEGVKSRPRQKKTQACLASKHVQEAPRLEPANEEHNVETAEDSEIRYLSADSGDADDSDADLGSAV

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for RNA polymerase I termination factor Antibody

Western Blot: RNA polymerase I termination factor Antibody [NBP2-38740]

Western Blot: RNA polymerase I termination factor Antibody [NBP2-38740]

Western Blot: RNA polymerase I termination factor Antibody [NBP2-38740] - Analysis in human cell line MOLT-4.
Immunocytochemistry/ Immunofluorescence: RNA polymerase I termination factor Antibody [NBP2-38740]

Immunocytochemistry/ Immunofluorescence: RNA polymerase I termination factor Antibody [NBP2-38740]

Immunocytochemistry/Immunofluorescence: RNA polymerase I termination factor Antibody [NBP2-38740] - Staining of human testis shows strong nuclear positivity in cells in seminiferous ducts.
Immunohistochemistry-Paraffin: RNA polymerase I termination factor Antibody [NBP2-38740]

Immunohistochemistry-Paraffin: RNA polymerase I termination factor Antibody [NBP2-38740]

Immunohistochemistry-Paraffin: RNA polymerase I termination factor Antibody [NBP2-38740] - Staining of human small intestine shows strong nuclear positivity in glandular cells.
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Applications for RNA polymerase I termination factor Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000

Western Blot

0.04 - 0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: RNA polymerase I termination factor

The TTF1 gene encodes a 905 amino acid long, 103 kDA transcription termination factor 1 protein, also known as a RNA polymerase I termination factor, which functions in terminating ribosomal gene transcription. Additionally, it regulates fork arrest replication and RNA polymerase I transcription on chromatin. Through monitoring the activation as well as the silencing of rDNA transcription, TTF1 acts in rDNA regulation. TTF1 functions in RNA polymerase I transcription as well as mitochondrial transcription and gene expression. It is known to interact with genes PTRF, NFATC3, BAZ2A, SMAD1, and SMAD7. TTF1 has been researched regarding its role in lung cancer, small cell carcinoma, sex cord-gonadal stromal tumor, thyroiditis, blastoma, adenocarcinoma, desmoplastic small round cell tumors, and hirschsprung's disease.

Alternate Names

RNA polymerase I termination factor, transcription termination factor 1, Transcription termination factor I, transcription termination factor, RNA polymerase I, TTF-1, TTF-I

Gene Symbol

TTF1

UniProt

Q15361 (Human)

Additional RNA polymerase I termination factor Products

Product Documents for RNA polymerase I termination factor Antibody

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Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for RNA polymerase I termination factor Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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