RNA polymerase I termination factor Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-10414

Novus Biologicals, part of Bio-Techne
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NBP3-10414-100ul
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Key Product Details

Species Reactivity

Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

0.5 mg/ml

View all RNA polymerase I termination factor Antibodies »

Product Specifications

Immunogen

The immunogen is a synthetic peptide directed towards the n terminal region of mouse RNA polymerase I termination factor (NP_033468). Peptide sequence RRASQTPAQETLESEWPQKAKRKKRRREPQTPAQETLESEWPQKAKKKKR

Clonality

Polyclonal

Host

Rabbit

Theoretical MW

98 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for RNA polymerase I termination factor Antibody

Western Blot: RNA polymerase I termination factor Antibody [NBP3-10414]

Western Blot: RNA polymerase I termination factor Antibody [NBP3-10414]

Western Blot: RNA polymerase I termination factor Antibody [NBP3-10414] - Western blot analysis of RNA polymerase I termination factor in Mouse Heart as a positive control. Antibody dilution at 0.2-1 ug/ml

Applications for RNA polymerase I termination factor Antibody

Application
Recommended Usage

Western Blot

1.0 ug/ml

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: RNA polymerase I termination factor

The TTF1 gene encodes a 905 amino acid long, 103 kDA transcription termination factor 1 protein, also known as a RNA polymerase I termination factor, which functions in terminating ribosomal gene transcription. Additionally, it regulates fork arrest replication and RNA polymerase I transcription on chromatin. Through monitoring the activation as well as the silencing of rDNA transcription, TTF1 acts in rDNA regulation. TTF1 functions in RNA polymerase I transcription as well as mitochondrial transcription and gene expression. It is known to interact with genes PTRF, NFATC3, BAZ2A, SMAD1, and SMAD7. TTF1 has been researched regarding its role in lung cancer, small cell carcinoma, sex cord-gonadal stromal tumor, thyroiditis, blastoma, adenocarcinoma, desmoplastic small round cell tumors, and hirschsprung's disease.

Alternate Names

RNA polymerase I termination factor, transcription termination factor 1, Transcription termination factor I, transcription termination factor, RNA polymerase I, TTF-1, TTF-I

Gene Symbol

TTF1

Additional RNA polymerase I termination factor Products

Product Documents for RNA polymerase I termination factor Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for RNA polymerase I termination factor Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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