RPSA Antibody (RPSA/6332R) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14110

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Kappa Clone # RPSA/6332R

Format

Azide and BSA Free

Concentration

1 mg/ml

View all RPSA Antibodies »

Product Specifications

Immunogen

Recombinant full-length human RPSA protein (Uniprot: P08865)

Localization

Cell Surface,Cytoplasmic and Nuclear

Marker

Marker of Metastatic Potential

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Description

1.0 mg/ml of antibody purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS WITHOUT BSA & azide. Also available at 200 ug/ml WITH BSA & azide (NBP3-13958).

Antibody without azide - store at -20 to -80C. Antibody with azide - store at 2 to 8C. Non-hazardous.

Theoretical molecular weight: 37-67kDa

Scientific Data Images for RPSA Antibody (RPSA/6332R) - Azide and BSA Free

RPSA Antibody (RPSA/6332R) - Azide and BSA Free

RPSA Antibody (RPSA/6332R)

Formalin-fixed, paraffin-embedded human pancreasstained with RPSA antibody (RPSA/6332R). HIER: Tris/EDTA, pH9.0, 45min. Secondary: HRP-polymer, 30min. DAB, 5min.
RPSA Antibody (RPSA/6332R) - Azide and BSA Free

RPSA Antibody (RPSA/6332R)

Formalin-fixed, paraffin-embedded human colonstained with RPSA antibody (RPSA/6332R). HIER: Tris/EDTA, pH9.0, 45min. Secondary: HRP-polymer, 30min. DAB, 5min.

Applications for RPSA Antibody (RPSA/6332R) - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

1-2 ug/ml
Application Notes
Immunohistochemistry (Formalin-fixed): 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10mM PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -80C. Avoid freeze-thaw cycles.

Background: RPSA

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. (provided by RefSeq)

Alternate Names

37 kDa laminin receptor precursor, 37/67 kDa laminin receptor, 37LRPNEM/1CHD4, 67 kDa laminin receptor, 67kD, ribosomal protein SA, 67LR, Colon carcinoma laminin-binding protein, LAMBR37 kDa laminin receptor, laminin binding protein, Laminin receptor 1, laminin receptor 1 (67kD, ribosomal protein SA), Laminin-binding protein precursor p40, lamR, LAMR 1, LAMR140S ribosomal protein SA, LBP, LBP/p40, LRP, LRP/LR, Multidrug resistance-associated protein MGr1-Ag, p40, ribosomal protein SA

Gene Symbol

RPSA

Additional RPSA Products

Product Documents for RPSA Antibody (RPSA/6332R) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for RPSA Antibody (RPSA/6332R) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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