RUVBL1 Antibody (01)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-06522

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 01

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all RUVBL1 Antibodies »

Product Specifications

Immunogen

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human RUVBL1 (Uniprot#: Q9Y265-1; Met1-Lys456).

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Description

This antibody can be stored at 2C-8C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20C to -80C. Avoid repeated freeze-thaw cycles.

Scientific Data Images for RUVBL1 Antibody (01)

Immunohistochemistry-Paraffin: RUVBL1 Antibody (01) [NBP3-06522]

Immunohistochemistry-Paraffin: RUVBL1 Antibody (01) [NBP3-06522]

Immunohistochemistry-Paraffin: RUVBL1 Antibody (01) [NBP3-06522] - Staining of human RUVBL1 in human testis with mouse monoclonal antibody (1:100000).
Immunohistochemistry-Paraffin: RUVBL1 Antibody (01) [NBP3-06522]

Immunohistochemistry-Paraffin: RUVBL1 Antibody (01) [NBP3-06522]

Immunohistochemistry-Paraffin: RUVBL1 Antibody (01) [NBP3-06522] - Staining of human RUVBL1 in human colon carcinoma with mouse monoclonal antibody (1:100000).

Applications for RUVBL1 Antibody (01)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:20000-1:100000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

0.2 um filtered solution in PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: RUVBL1

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex

Alternate Names

49 kDa TATA box-binding protein-interacting protein, 54 kDa erythrocyte cytosolic protein, EC 3.6.1, EC 3.6.4.12,49 kDa TBP-interacting protein, ECP54, INO80 complex subunit H, INO80HTIP49A, NMP 238, NMP238ECP-54, Nuclear matrix protein 238, PONTIN, Pontin 52, Pontin52, RuvB (E coli homolog)-like 1, ruvB-like 1, RuvB-like 1 (E. coli), Rvb1, TATA binding protein interacting protein 49 kDa, TIH1, TIP49a, TIP49TAP54-alpha, TIP60-associated protein 54-alpha

Gene Symbol

RUVBL1

Additional RUVBL1 Products

Product Documents for RUVBL1 Antibody (01)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for RUVBL1 Antibody (01)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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