Ryanodine Receptor 1 Antibody (C4)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-42080

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # C4

Concentration

1 mg/ml

View all Ryanodine Receptor 1 Antibodies »

Product Specifications

Immunogen

Immunized with recombinant Rat Ryanodine Receptor 1 (Uniprot#: F1LMY4; His99-Cys394 (Uniprot#: F1LMY4)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Applications for Ryanodine Receptor 1 Antibody (C4)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

5-20ug/mL

Immunohistochemistry

5-20ug/mL

Western Blot

0.2-2ug/mL
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS, pH7.4, 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Ryanodine Receptor 1

The Ryanodine Receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the "foot" region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR 1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR 2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).

Long Name

Ryanodine receptor 1

Alternate Names

RYDR, RYR-1, RyR1

Gene Symbol

RYR1

Additional Ryanodine Receptor 1 Products

Product Documents for Ryanodine Receptor 1 Antibody (C4)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Ryanodine Receptor 1 Antibody (C4)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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