Ryanodine Receptor 1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-33785

Novus Biologicals, part of Bio-Techne
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NBP2-33785
NBP2-33785-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (96%), Rat (96%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Ryanodine Receptor 1 Antibodies »

Product Summary for Ryanodine Receptor 1 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: REFLHNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEVSAVLYYLDQTEHPYKSKK

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Ryanodine Receptor 1 Antibody

Immunohistochemistry-Paraffin: Ryanodine Receptor 1 Antibody [NBP2-33785]

Immunohistochemistry-Paraffin: Ryanodine Receptor 1 Antibody [NBP2-33785]

Immunohistochemistry-Paraffin: Ryanodine Receptor 1 Antibody [NBP2-33785] - Staining in human skeletal muscle and colon tissues using anti-RYR1 antibody. Corresponding RYR1 RNA-seq data are presented for the same tissues.
Immunocytochemistry/ Immunofluorescence: Ryanodine Receptor 1 Antibody [NBP2-33785]

Immunocytochemistry/ Immunofluorescence: Ryanodine Receptor 1 Antibody [NBP2-33785]

Immunocytochemistry/Immunofluorescence: Ryanodine Receptor 1 Antibody [NBP2-33785] - Staining of human cell line SiHa shows localization to cytosol & the Golgi apparatus. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Ryanodine Receptor 1 Antibody [NBP2-33785]

Immunohistochemistry-Paraffin: Ryanodine Receptor 1 Antibody [NBP2-33785]

Immunohistochemistry-Paraffin: Ryanodine Receptor 1 Antibody [NBP2-33785] - Staining of human skeletal muscle shows high expression.
View 1 more images

Applications for Ryanodine Receptor 1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Ryanodine Receptor 1

The Ryanodine Receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the "foot" region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR 1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR 2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).

Long Name

Ryanodine receptor 1

Alternate Names

RYDR, RYR-1, RyR1

Gene Symbol

RYR1

UniProt

P21817 (Human)

Additional Ryanodine Receptor 1 Products

Product Documents for Ryanodine Receptor 1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Ryanodine Receptor 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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