S100A1 Antibody (D28-E)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-30154

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
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NBP1-30154-500ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # D28-E

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all S100A1 Antibodies »

Product Summary for S100A1 Antibody (D28-E)

Immunogen

Peptide derived from N-terminal sequence of human S100A1 protein. Antibody recognizes the epitope between Val55 - Glu74.

Epitope

Val55 - Glu74

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Description

This antibody is immunoaffinity purified with immunogenic peptide as a ligand.

Scientific Data Images for S100A1 Antibody (D28-E)

Immunohistochemistry-Paraffin: S100A1 Antibody (D28-E) [NBP1-30154]

Immunohistochemistry-Paraffin: S100A1 Antibody (D28-E) [NBP1-30154]

Immunohistochemistry-Paraffin: S100A/B Antibody (D28-E) [NBP1-30154] - S-100 protein expression in the cutaneous malignant melanoma. Formalin fixed, paraffin embedded human tissue (4 um section) stained with anti - S-100 monospecific clonal antibody.

Applications for S100A1 Antibody (D28-E)

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:100-1:200
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

20mM Tris-HCl (pH 8.0) and 20mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: S100A1

S100A/B belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100A/B protein may function in stimulation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. Immunoreactive S100 protein localizes in the cytoplasm and nuclei of astrocytes, Schwann's cells, ependymomas and astrogliomas. Ganglion cells do not stain for S100A/B protein. S100A/B can be detected in almost all benign naevi and malignant melanocytic tumors of the skin, and in Langerhans cells in the skin.

Long Name

S100 Calcium Binding Protein A1

Alternate Names

protein S100-A1, S100 alpha, S100 calcium binding protein A1, S100 calcium-binding protein A1S100, S-100 protein alpha chain, S-100 protein subunit alpha, S100 protein, alpha polypeptide, S100A, S100-alpha

Entrez Gene IDs

6285 (Human); 6271 (Human)

Gene Symbol

S100B

UniProt

P23297

Additional S100A1 Products

Product Documents for S100A1 Antibody (D28-E)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for S100A1 Antibody (D28-E)

This antibody is immunoaffinity purified with immunogenic peptide as a ligand.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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