S100A1 Antibody (S100A1/1942) - Azide and BSA Free

Validated:

Unconjugated

Monoclonal Mouse IgG₁ kappa Clone # S100A1/1942

Azide and BSA Free

0.2 mg/ml

Recombinant human full-length S100A1 protein

Cytoplasmic

The family of EF-hand type Ca2+-binding proteins includes calbindin, S-100 alpha and beta, calgranulins, B and C, and the parvalbumin family members, including parvalbumin alpha and parvalbumin beta. The S-100 protein is involved in the regulation of cellular processes such as cell cycle progression and differentiation. S-100 protein may function in the activation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly and inhibition of protein kinase C mediated phosphorylation. Two S-100 subunits, sharing 60% sequence identity, have been described as S-100 alpha chain and S-100 beta chain. Three S-100 dimeric forms have been characterized, differing in their subunit composition of two alpha chains, two beta chains or one alpha and one beta chain. S-100 localizes to the cytoplasm and nuclei of astrocytes, Schwann s cells, ependymomas and astrogliomas. S-100 is also detected in almost all benign naevi, malignant melanocytic tumours and in Langerhans cells in the skin. Calbindin, S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S-100 alpha and beta are present in a variety of other tissues and calbindin is present in intestine and kidney.

Astrocyte Marker

Monoclonal

Mouse

IgG₁ kappa

Purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS WITHOUT BSA & azide at 1.0 mg/ml.

Protein A or G purified

10 mM PBS with 0.05% BSA

Azide and BSA Free

No Preservative

0.2 mg/ml

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.