SHP-1 Antibody (S06-4C8)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19611

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19611-50ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S06-4C8

Concentration

0.3 mg/ml

View all SHP-1 Antibodies »

Product Summary for SHP-1 Antibody (S06-4C8)

Immunogen

A synthetic peptide of human SHP-1 (Uniprot # P29350)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

68 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SHP-1 Antibody (S06-4C8)

Western Blot: SHP-1 Antibody (S06-4C8) [NBP3-19611]

Western Blot: SHP-1 Antibody (S06-4C8) [NBP3-19611]

Western Blot: SHP-1 Antibody (S06-4C8) [NBP3-19611] - Western blot detection of SHP-1 in Jurkat cell lysates using NBP3-19611 (1:500 diluted). Predicted band size: 68kDa. Observed band size: 68kDa.
Immunohistochemistry-Paraffin: SHP-1 Antibody (S06-4C8) [NBP3-19611]

Immunohistochemistry-Paraffin: SHP-1 Antibody (S06-4C8) [NBP3-19611]

Immunohistochemistry-Paraffin: SHP-1 Antibody (S06-4C8) [NBP3-19611] - Immunohistochemistry of SHP-1 in paraffin-embedded Human tonsil using NBP3-19611 at dilution 1/50

Applications for SHP-1 Antibody (S06-4C8)

Application
Recommended Usage

Immunohistochemistry

1/200-1/500

Western Blot

1/1000-1/5000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SHP-1

The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.

Long Name

Src Homology Region 2 Domain Phosphatase 1

Alternate Names

HCPH, PTP1C, PTPN6, SHP1

Gene Symbol

PTPN6

Additional SHP-1 Products

Product Documents for SHP-1 Antibody (S06-4C8)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SHP-1 Antibody (S06-4C8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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