SHP/NR0B2/Nuclear Receptor SHP Antibody (1A11)

Novus Biologicals, part of Bio-Techne | Catalog # H00008431-M01

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Sandwich ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 1A11

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all SHP/NR0B2 Antibodies »

Product Specifications

Immunogen

NR0B2 (AAH30207, 1 a.a. ~ 257 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MSTSQPGACPCQGAASRPAILYALLSSSLKAVPRPRSRCLCRQHRPVQLCAPHRTCREALDVLAKTVAFLRNLPSFWQLPPQDQRRLLQGCWGPLFLLGLAQDAVTFEVAEAPVPSILKKILLEEPSSSGGSGQLPDRPQPSLAAVQWLQCCLESFWSLELSPKEYACLKGTILFNPDVPGLQAASHIGHLQQEAHWVLCEVLEPWCPAAQGRLTRVLLTASTLKSIPTSLLGDLFFRPIIGDVDIAGLLGDMLLLR

Specificity

nuclear receptor subfamily 0, group B, member 2

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for SHP/NR0B2/Nuclear Receptor SHP Antibody (1A11)

Western Blot: SHP/NR0B2/Nuclear Receptor SHP Antibody (1A11) [H00008431-M01]

Western Blot: SHP/NR0B2/Nuclear Receptor SHP Antibody (1A11) [H00008431-M01]

Western Blot: SHP/NR0B2/Nuclear Receptor SHP Antibody (1A11) [H00008431-M01] - NR0B2 monoclonal antibody (M01), clone 1A11. Analysis of NR0B2 expression in human colon.
Immunocytochemistry/ Immunofluorescence: SHP/NR0B2/Nuclear Receptor SHP Antibody (1A11) [H00008431-M01]

Immunocytochemistry/ Immunofluorescence: SHP/NR0B2/Nuclear Receptor SHP Antibody (1A11) [H00008431-M01]

Immunocytochemistry/Immunofluorescence: SHP/NR0B2/Nuclear Receptor SHP Antibody (1A11) [H00008431-M01] - Analysis of monoclonal antibody to NR0B2 on HeLa cell . Antibody concentration 10 ug/ml.
Sandwich ELISA: SHP/NR0B2/Nuclear Receptor SHP Antibody (1A11) [H00008431-M01] - Detection limit for recombinant GST tagged NR0B2 is approximately 3ng/ml as a capture antibody.

Applications for SHP/NR0B2/Nuclear Receptor SHP Antibody (1A11)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Sandwich ELISA

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Antibody reactivity against recombinant protein on ELISA. GST alone used as a negative control.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: SHP/NR0B2

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.

Long Name

Small Heterodimer Partner

Alternate Names

NR0B2

Entrez Gene IDs

8431 (Human)

Gene Symbol

NR0B2

OMIM

601665 (Human)

UniProt

AAH30207 (Human)

Additional SHP/NR0B2 Products

Product Documents for SHP/NR0B2/Nuclear Receptor SHP Antibody (1A11)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SHP/NR0B2/Nuclear Receptor SHP Antibody (1A11)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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