Key Product Details

Species Reactivity

Validated:

Human, Mouse

Predicted:

Rat (100%). Backed by our 100% Guarantee.

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all SIGIRR Antibodies »

Product Specifications

Immunogen

Antibody was raised against a synthetic peptide corresponding to 15 amino acids at the C-terminus of human SIGIRR. The immunogen is located within the last 50 amino acids of SIGIRR. Amino Acid Squence: SDLGSRNYSARTDFY

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

45 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SIGIRR Antibody - BSA Free

Western Blot: SIGIRR AntibodyBSA Free [NBP1-76599]

Western Blot: SIGIRR AntibodyBSA Free [NBP1-76599]

Western Blot: SIGIRR Antibody [NBP1-76599] - Analysis of SIGIRR in A549 cell lysate with SIGIRR antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
Immunocytochemistry/ Immunofluorescence: SIGIRR Antibody - BSA Free [NBP1-76599]

Immunocytochemistry/ Immunofluorescence: SIGIRR Antibody - BSA Free [NBP1-76599]

Immunocytochemistry/Immunofluorescence: SIGIRR Antibody [NBP1-76599] - Immunocytochemical analysis of SIGIRR in formalin-fixed A549 cells with SIGIRR antibody at 10 ug/ml.
SIGIRR Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: SIGIRR Antibody - BSA Free [NBP1-76599] -

Immunocytochemistry/ Immunofluorescence: SIGIRR Antibody - BSA Free [NBP1-76599] - Immunocytochemistry of SIGIRR in A549 cells with SIGIRR antibody at 10 u/mL.
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Applications for SIGIRR Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

10 ug/ml

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SIGIRR

SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.

Long Name

Single lg IL-1 Related Protein

Alternate Names

IL-1R8, TIR8

Gene Symbol

SIGIRR

UniProt

CAG33619 (Human)

Additional SIGIRR Products

Product Documents for SIGIRR Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for SIGIRR Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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