SIGLECL12 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-20362

Novus Biologicals, part of Bio-Techne
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NBP2-20362
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Primate (96%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Siglec-12 Antibodies »

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the center region of human SIGLECL12. The exact sequence is proprietary.

Reactivity Notes

Chimpanzee (96%).

Localization

Membrane; Single-pass type I membrane protein

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

65 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SIGLECL12 Antibody

Western Blot: SIGLECL12 Antibody [NBP2-20362]

Western Blot: SIGLECL12 Antibody [NBP2-20362]

Western Blot: SIGLECL1 Antibody [NBP2-20362] - Sample (30 ug of whole cell lysate) A: MCF-7 7. 5% SDS PAGE gel, diluted at 1:2000.
Immunohistochemistry-Paraffin: SIGLECL12 Antibody [NBP2-20362]

Immunohistochemistry-Paraffin: SIGLECL12 Antibody [NBP2-20362]

Immunohistochemistry-Paraffin: SIGLECL1 Antibody [NBP2-20362] - Immunohistochemical analysis of paraffin-embedded Lung CA, using antibody at 1:250 dilution.

Applications for SIGLECL12 Antibody

Application
Recommended Usage

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:3000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

0.1M Tris (pH 7), 0.1M Glycine, 20% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Siglec-12

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq]

Long Name

Sialic Acid Binding Ig-like Lectin 12

Alternate Names

S2V, Siglec-XII, SIGLECL1, SLG

Gene Symbol

SIGLEC12

UniProt

Q96PQ1 (Human)

Additional Siglec-12 Products

Product Documents for SIGLECL12 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for SIGLECL12 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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