Sigma-1 R/OPRS1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-19628

Novus Biologicals, part of Bio-Techne
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NBP2-19628
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Key Product Details

Validated by

Knockout/Knockdown

Species Reactivity

Validated:

Human, Zebrafish

Cited:

Human

Predicted:

Bovine (97%), Guinea Pig (96%), Mouse (94%), Rat (96%), Rhesus Macaque (100%). Backed by our 100% Guarantee.

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Knockout Validated, Western Blot

Cited:

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Sigma-1 R Antibodies »

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the center region of human Sigma-1 R/OPRS1. The exact sequence is proprietary.

Localization

Nucleus inner membrane; Nucleus outer membrane; Endoplasmic reticulum membrane; Lipid droplet; Cell junction; Cell membrane; Cell projection; growth cone

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

25 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Sigma-1 R/OPRS1 Antibody

Western Blot: Sigma-1 R/OPRS1 Antibody [NBP2-19628]

Western Blot: Sigma-1 R/OPRS1 Antibody [NBP2-19628]

Western Blot: Sigma-1 R/OPRS1 Antibody [NBP2-19628] - Wild-type (WT) and SIGMAR1 knockout (KO) 293T cell extracts (30 ug) were separated by 12% SDS-PAGE, and the membrane was blotted with Sigma-1 R Antibody diluted at 1:500. HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Immunohistochemistry-Paraffin: Sigma-1 R/OPRS1 Antibody [NBP2-19628]

Immunohistochemistry-Paraffin: Sigma-1 R/OPRS1 Antibody [NBP2-19628]

Immunohistochemistry-Paraffin: Sigma-1 R/OPRS1 Antibody [NBP2-19628] - Analysis of paraffin-embedded SW480 xenograft, using antibody at 1:100 dilution.
Sigma-1 R/OPRS1 Antibody

Western Blot: Sigma-1 R/OPRS1 Antibody [NBP2-19628] -

Western Blot: Sigma-1 R/OPRS1 Antibody [NBP2-19628] - Various tissue extracts (50 ug) were separated by 12% SDS-PAGE, and the membrane was blotted with Sigma-1 R/OPRS1 antibody [N1C3] (NBP2-19628) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
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Applications for Sigma-1 R/OPRS1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:3000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS (pH 7), 20% Glycerol

Preservative

0.025% Proclin 300

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Sigma-1 R

This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq]

Long Name

Sigma Non-opioid Intracellular Receptor 1

Alternate Names

ALS16, OPRS1, SIG-1R, Sigma-1R, Sigma1R, SIGMAR1, SRBP

Gene Symbol

SIGMAR1

UniProt

Q99720

Additional Sigma-1 R Products

Product Documents for Sigma-1 R/OPRS1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Sigma-1 R/OPRS1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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