SIM2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-68864

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Mouse

Predicted:

Human (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all SIM2 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-SDLLYTPSYS corresponding to internal region according to NP_033664.2.

Epitope

C-SDLLYTPSYS

Specificity

This antibody is expected to recognize all reported isoforms (NP_005060.1; NP_033664.2).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for SIM2 Antibody

Western Blot: SIM2 Antibody [NBP1-68864]

Western Blot: SIM2 Antibody [NBP1-68864]

Western Blot: SIM2 Antibody [NBP1-68864] - (0.5ug/ml) staining of fetal Mouse kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for SIM2 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:1000

Western Blot

0.5 - 2 ug/ml
Application Notes
WB: Approx. 80 kDa band observed in fetal mouse kidney lysates (calculated MW of 73.2 kDa band according to human NP_005060.1) and 72.5 kDa band according to mouse NP_035507.2.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: SIM2

SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal region. Based on the mapping position, its potential function as transcriptional repressor and similarity to Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypes

Alternate Names

human transcription factor SIM2, homolog of the Drosophila single-minded geneSIM110BHLHE15, short isoform, single-minded (Drosophila) homolog 2, single-minded homolog 2 (Drosophila), transcription factor SIM2

Entrez Gene IDs

6493 (Human); 20465 (Mouse); 304071 (Rat)

Gene Symbol

SIM2

UniProt

NP_005060.1 (Human)

Additional SIM2 Products

Product Documents for SIM2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SIM2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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