SIX4 Antibody (7E2)

ELISA: SIX4 Antibody (7E2) [H00051804-M09]

ELISA: SIX homeobox 4 Antibody (7E2) [H00051804-M09] - Detection limit for recombinant GST tagged SIX4 is approximately 0.1ng/ml as a capture antibody.

Knockdown Validated: SIX4 Antibody (7E2) [H00051804-M09]

Knockdown Validated: SIX4 Antibody (7E2) [H00051804-M09] - Immunoblots indicate consequence of SIX4 depletion on LKB1 accumulation and AMPK pathway activation. Image collected and cropped by CiteAb from the following publication (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704493/) licensed under a CC-BY license.

Western Blot: SIX4 Antibody (7E2) [H00051804-M09] -

Western Blot: SIX4 Antibody (7E2) [H00051804-M09] - Selective addiction of EOC to the SIX4 homeobox transcription factorImmunoblots indicate miR‐124‐induced SIX4 depletion. siSIX4 is shown as an antibody control.Consequence of SIX4 depletion on EOC cell viability (as in Fig 2A, N, normal cell lines: HOSE, HBEC30).In vivo knockdown of SIX4 using neutral liposome‐incorporated siRNA reduced tumor burden & ascites volume in an orthotopic xenograft mouse model. Box‐and‐whisker plot of tumor weight (left panel) or ascites volume (right panel) from n = 7 or 8 mice per condition as indicated. *P‐value from Student's t‐test.Consequence of SIX4 depletion in PEO1 cells on E‐cadherin plasma membrane accumulation 48 h after transfection. Cells were counterstained with phalloidin & DAPI.Immunoblots indicate consequence of SIX4 depletion on LKB1 accumulation & AMPK pathway activation.Source data are available online for this figure. Image collected & cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/26655797), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Western Blot: SIX4 Antibody (7E2) [H00051804-M09] -

Western Blot: SIX4 Antibody (7E2) [H00051804-M09] - Selective addiction of EOC to the SIX4 homeobox transcription factorImmunoblots indicate miR‐124‐induced SIX4 depletion. siSIX4 is shown as an antibody control.Consequence of SIX4 depletion on EOC cell viability (as in Fig 2A, N, normal cell lines: HOSE, HBEC30).In vivo knockdown of SIX4 using neutral liposome‐incorporated siRNA reduced tumor burden & ascites volume in an orthotopic xenograft mouse model. Box‐and‐whisker plot of tumor weight (left panel) or ascites volume (right panel) from n = 7 or 8 mice per condition as indicated. *P‐value from Student's t‐test.Consequence of SIX4 depletion in PEO1 cells on E‐cadherin plasma membrane accumulation 48 h after transfection. Cells were counterstained with phalloidin & DAPI.Immunoblots indicate consequence of SIX4 depletion on LKB1 accumulation & AMPK pathway activation.Source data are available online for this figure. Image collected & cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/26655797), licensed under a CC-BY license. Not internally tested by Novus Biologicals.