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SLC39A1 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76498

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human

Applications

Validated:

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

Product Specifications

Immunogen

Antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human ZIP1. The immunogen is located within amino acids 40 - 90 of ZIP1. Amino Acid Squence: LRRPGANHEGSASRQK

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Bovine: (88%)

Specificity

At least two isoforms of ZIP1 are known to exist; this antibody will detect both isoforms. ZIP1 antibody is predicted not to cross-react with other ZIP family proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

38 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SLC39A1 Antibody - BSA Free

Western Blot: SLC39A1 AntibodyBSA Free [NBP1-76498]

Western Blot: SLC39A1 AntibodyBSA Free [NBP1-76498]

Western Blot: SLC39A1 Antibody [NBP1-76498] - Mouse kidney tissue lysate with ZIP1 antibody at (A) 1 and (B) 2 ug/mL.
Immunocytochemistry/ Immunofluorescence: SLC39A1 Antibody - BSA Free [NBP1-76498]

Immunocytochemistry/ Immunofluorescence: SLC39A1 Antibody - BSA Free [NBP1-76498]

Immunocytochemistry/Immunofluorescence: SLC39A1 Antibody [NBP1-76498] - ZIP1 in human kidney tissue.
Immunohistochemistry: SLC39A1 Antibody - BSA Free [NBP1-76498]

Immunohistochemistry: SLC39A1 Antibody - BSA Free [NBP1-76498]

Immunohistochemistry: SLC39A1 Antibody [NBP1-76498] - Human kidney tissue at 2.5 ug/mL. dilution

Applications for SLC39A1 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/mL

Immunohistochemistry

2.5 ug/ml

Immunohistochemistry-Paraffin

2.5 ug/mL

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SLC39A1

ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-kappaB, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.

Alternate Names

CGI-08, CGI-71, IRT1, solute carrier family 39 (zinc transporter), member 1, solute carrier family 39 (zinc transporter), member 3, ZIP1, ZIP-1

Gene Symbol

SLC39A1

Additional SLC39A1 Products

Product Documents for SLC39A1 Antibody - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for SLC39A1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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