SLPI Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76396

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Mouse

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all SLPI Antibodies »

Product Summary for SLPI Antibody - BSA Free

Immunogen

Antibody was raised against a 17 amino acid synthetic peptide from near the center of mouse SLPI. The immunogen is located within amino acids 60 - 110 of SLPI. Amino Acid Squence: CVNPVPIRKPVWRKPGR

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SLPI Antibody - BSA Free

Western Blot: SLPI AntibodyBSA Free [NBP1-76396]

Western Blot: SLPI AntibodyBSA Free [NBP1-76396]

Western Blot: SLPI Antibody [NBP1-76396] - Analysis in A-20 cell lysate with antibody at (A) 1 and (B) 2 ug/mL.

Applications for SLPI Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Western Blot

1-2 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SLPI

Secretory leukocyte protease inhibitor (SLPI) is produced at mucosal surfaces, primarily the upper respiratory tract and is thought to play an important role in the antiprotease defense mechanism of the lung. SLPI forms inhibitory complexes with numerous proteolytic enzymes such as neutrophil elastase, and has been shown to possess anti-inflammatory, anti-viral, and antibacterial activities. Its expression in oral epithelial cells is stimulated by HIV-1 gp120, suggesting that SLPI is a component of the oral mucosal response to HIV-1. In peripheral blood monocytes, SLPI can inhibit NF-kappaB activation by inhibiting IkappaB degradation in the cytoplasm and competing for NF-kappaB binding sites in the nucleus. This attenuation of the inflammatory response may also act to suppress liver metastases and other cancer cell invasions, but promote blood-borne metastasis via an invasion-independent pathway.

Long Name

Secretory Leukocyte Protease Inhibitor

Alternate Names

ALK1, ALPProtease inhibitor WAP4, antileukoproteinase, BLPISeminal proteinase inhibitor, HUSI, HUSI-I, Mucus proteinase inhibitor, secretory leukocyte peptidase inhibitor, Secretory leukocyte protease inhibitor, secretory leukocyte protease inhibitor (antileukoproteinase), WAP four-disulfide core domain protein 4, WAP4HUSI-1, WFDC4MPI

Gene Symbol

SLPI

UniProt

NP_035544 (Mouse)

Additional SLPI Products

Product Documents for SLPI Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SLPI Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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