SOCS-1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-58943

Novus Biologicals, part of Bio-Techne
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NBP1-58943
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all SOCS-1 Antibodies »

Product Specifications

Immunogen

This SOCS-1 antibody is made to synthetic peptides corresponding to SOCS1 (suppressor of cytokine signaling 1). The peptide sequence was selected from the N terminal of SOCS1. Peptide sequence RRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRA. The peptide sequence for this immunogen was taken from within the described region.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Scientific Data Images for SOCS-1 Antibody

Western Blot: SOCS-1 Antibody [NBP1-58943]

Western Blot: SOCS-1 Antibody [NBP1-58943]

Western Blot: SOCS-1 Antibody [NBP1-58943] - Lanes: 1. Mouse WT brain extract (80ug) 2. Rat brain extract (80ug) Primary Antibody Dilution: 2ug/ml Secondary Antibody: IRDye 800CW goat anti-rabbit from Li-COR Bioscience Secondary Antibody Dilution: 1: 20,000 Gene Name: SOCS1
Immunohistochemistry: SOCS-1 Antibody [NBP1-58943]

Immunohistochemistry: SOCS-1 Antibody [NBP1-58943]

Immunohistochemistry: SOCS-1 Antibody [NBP1-58943] - Paraffin Embedded Tissue: Human Kidney Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4.0 - 8.0 ug/ml Magnification: 400X
Western Blot: SOCS-1 Antibody [NBP1-58943]

Western Blot: SOCS-1 Antibody [NBP1-58943]

Western Blot: SOCS-1 Antibody [NBP1-58943] - Jurkat Lysate (20 ug). Antibody at 1.25 ug/mL.
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Applications for SOCS-1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:10 - 1:500

Immunohistochemistry-Paraffin

1:10 - 1:500

Western Blot

1.0 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SOCS-1

SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. SOCS1 functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of its gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

Long Name

Suppressor Of Cytokine Signaling 1

Alternate Names

CIS1, Cish1, JAB, SOCS1, SSI-1, TIP3

Gene Symbol

SOCS1

UniProt

O15524 (Human)

Additional SOCS-1 Products

Product Documents for SOCS-1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SOCS-1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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