SOCS-2 Antibody (SR3830)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-27811

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-27811-100ul
NBP3-27811-50ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR3830

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SOCS-2 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human SOCS-2 (Uniprot #: O14508)

Specificity

Detects endogenous levels of total SOCS-2

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

22 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SOCS-2 Antibody (SR3830)

Western Blot: SOCS-2 Antibody (SR3830) [NBP3-27811] -

Western Blot: SOCS-2 Antibody (SR3830) [NBP3-27811] - Western blot analysis of SOCS-2 expression in K562 cell lysate.

Applications for SOCS-2 Antibody (SR3830)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunoprecipitation

1:50

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 150mM NaCl, 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SOCS-2

Accumulating evidence demonstrates that cytokine receptorsignaling is negatively regulated by a family of Srchomology 2 domain-containing adaptor molecules TermedSOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have beenrecognized, they are SOCS 1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an Nterminalregion of variable length and amino acidcomposition, a central SH2 domain, and a previouslyunrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of aclassical negative feed back loop that regulates cytokinesignal transduction via a STAT induced transcriptionalmechanism. Transcription of each of the SOCS genesoccurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCSfamily appear to inhibit signaling in different ways. SOCS 2, not like SOCS 1 and SOCS 3, regulates postnatalgrowth, likely through its ability to influence the GH / IGF 1axis, although they might have overlapping actions.

Long Name

Suppressor Of Cytokine Signaling 2

Alternate Names

CIS2, Cish2, SOCS2, SSI2, STATI2

Gene Symbol

SOCS2

Additional SOCS-2 Products

Product Documents for SOCS-2 Antibody (SR3830)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SOCS-2 Antibody (SR3830)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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