SOCS-3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-27116

Novus Biologicals, part of Bio-Techne
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NBP2-27116
NBP2-27116SS
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Chinese Hamster (100%), Equine (100%), Guinea Pig (100%), Mouse (100%), Porcine (100%), Primate (100%), Rat (100%), Rhesus Macaque (100%), Sheep (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all SOCS-3 Antibodies »

Product Specifications

Immunogen

A portion of amino acids 170-220 from human SOCS3 was used as the immunogen for this antibody.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SOCS-3 Antibody

Immunohistochemistry-Paraffin: SOCS-3 Antibody [NBP2-27116]

Immunohistochemistry-Paraffin: SOCS-3 Antibody [NBP2-27116]

Immunohistochemistry-Paraffin: SOCS-3 Antibody [NBP2-27116] - Analysis of SOCS3 in human brain probed with SOCS3 antibody at 5 ug/ml.

Applications for SOCS-3 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

5ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

0.2 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SOCS-3

SOCS3 is a member of the suppressor of cytokine signaling family with a molecular weight of ~ 25kDa. It is also an SSI or stat-induced stat inhibitor protein. IL-6, for example, induces SOCS3 expression and in turn SOCS3 negatively regulates IL-6 induced immune signaling and inflammatory pathways. SOCS3 is also induced by IL-10 and IFNgamma (1-3). SOCS3 plays an important role in the initial stages of B cell development and differentiation (1). IL-6, IL-10, and IFNgamma feedback loops and likely involvement of SOCS3 may also be critical in controlling and fine-tuning the inflammatory responses of activated macrophages through TLR ligands, a direct involvement therefore of SOCS3 in innate immune signaling pathways (4, 5). SOCS3 antibody provides an opportunity to identify and clarify the SOCS3 feedback control mechanism in host defense, innate immunity or autoimmune inflammatory cascades.

Long Name

Suppressor Of Cytokine Signaling 3

Alternate Names

ATOD4, CIS3, Cish3, SOCS3, SSI-3

Gene Symbol

SOCS3

Additional SOCS-3 Products

Product Documents for SOCS-3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SOCS-3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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