Sorbitol Dehydrogenase Antibody (10F4) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-42653

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 10F4

Format

BSA Free

Concentration

1 mg/ml

View all Sorbitol Dehydrogenase Antibodies »

Product Summary for Sorbitol Dehydrogenase Antibody (10F4) - BSA Free

Immunogen

Recombinant human Sorbitol Dehydrogenase (1-357aa) purified from E. coli

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for Sorbitol Dehydrogenase Antibody (10F4) - BSA Free

Western Blot: Sorbitol Dehydrogenase Antibody (10F4)BSA Free [NBP2-42653]

Western Blot: Sorbitol Dehydrogenase Antibody (10F4)BSA Free [NBP2-42653]

Western Blot: Sorbitol Dehydrogenase Antibody (10F4) [NBP2-42653] - The cell lysates of Jurkat (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human Sorbitol Dehydrogenase antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Applications for Sorbitol Dehydrogenase Antibody (10F4) - BSA Free

Application
Recommended Usage

Western Blot

1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4), 10% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Sorbitol Dehydrogenase

Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme. SDH is expressed almost ubiquitously in all mammalian tissues. The enzyme has attracted considerable interest due to its implication in the development of diabetic complications as the polyol pathway is particularly active in hyperglycemic states. Although SORD is closely related to the class I long-chain alcohol dehydrogenases, it differs in substrate specificity, catalyzing polyols such as sorbitol and xylitol but having no activity towards primary alcohols.

Alternate Names

EC 1.1.1, EC 1.1.1.14, L-iditol 2-dehydrogenase, sorbitol dehydrogenase, SORD1

Gene Symbol

SORD

UniProt

AAH25295 (Human)

Additional Sorbitol Dehydrogenase Products

Product Documents for Sorbitol Dehydrogenase Antibody (10F4) - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Sorbitol Dehydrogenase Antibody (10F4) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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