SorLA Antibody (SR1433)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-22079

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-22079-100ul
NBP3-22079-50ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1433

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SorLA Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human SorLA (Uniprot #: Q92673)

Specificity

Detects endogenous levels of total SorLA

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

270 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SorLA Antibody (SR1433)

Western Blot: SorLA Antibody (SR1433) [NBP3-22079] -

Western Blot: SorLA Antibody (SR1433) [NBP3-22079] - Western blot analysis using NBP3-22079 in SH-SY5Y cell lysate.

Applications for SorLA Antibody (SR1433)

Application
Recommended Usage

Immunohistochemistry

1:100-1:500

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SorLA

SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.

Long Name

Sortilin-related Receptor Containing LDLR Class A Repeats

Alternate Names

gp250, LR11, LRP9, SORL1

Gene Symbol

SORL1

Additional SorLA Products

Product Documents for SorLA Antibody (SR1433)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SorLA Antibody (SR1433)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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