Sortilin Antibody (S02-6B4)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-15095

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S02-6B4

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Sortilin Antibodies »

Product Summary for Sortilin Antibody (S02-6B4)

Immunogen

Recombinant protein of human Sortilin (Uniprot#: Q99523)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

92 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Sortilin Antibody (S02-6B4)

Western Blot: Sortilin Antibody (S02-6B4) [NBP3-15095]

Western Blot: Sortilin Antibody (S02-6B4) [NBP3-15095]

Western Blot: Sortilin Antibody (S02-6B4) [NBP3-15095] - Western blot detection of Sortilin in Hela, A549, MCF-7 cell lysates using Sortilin Rabbit mAb (1:1000 diluted). Predicted band size: 92kDa. Observed band size: 92kDa.
Immunohistochemistry-Paraffin: Sortilin Antibody (S02-6B4) [NBP3-15095]

Immunohistochemistry-Paraffin: Sortilin Antibody (S02-6B4) [NBP3-15095]

Immunohistochemistry-Paraffin: Sortilin Antibody (S02-6B4) [NBP3-15095] - Immunohistochemistry of Sortilin in paraffin-embedded Human lung cancer tissue using Sortilin Rabbit mAb at dilution 1/50

Applications for Sortilin Antibody (S02-6B4)

Application
Recommended Usage

Immunohistochemistry

1/500

Western Blot

1/1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Sortilin

Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.

Alternate Names

Gp95, Ntr3, SORT1

Gene Symbol

SORT1

Additional Sortilin Products

Product Documents for Sortilin Antibody (S02-6B4)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Sortilin Antibody (S02-6B4)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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