Spectrin beta 3 Antibody
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-48794
Key Product Details
Validated by
Orthogonal Validation
Species Reactivity
Validated:
Human
Predicted:
Mouse (95%), Rat (95%). Backed by our 100% Guarantee.
Applications
Immunohistochemistry, Immunohistochemistry-Paraffin
Label
Unconjugated
Antibody Source
Polyclonal Rabbit IgG
Concentration
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: RLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASA
Clonality
Polyclonal
Host
Rabbit
Isotype
IgG
Scientific Data Images for Spectrin beta 3 Antibody
Immunohistochemistry-Paraffin: Spectrin beta 3 Antibody [NBP2-48794]
Immunohistochemistry-Paraffin: Spectrin beta 3 Antibody [NBP2-48794] - Staining of human skin shows high expression.Immunohistochemistry: Spectrin beta 3 Antibody [NBP2-48794]
Immunohistochemistry: Spectrin beta 3 Antibody [NBP2-48794] - Staining of human kidney shows strong cytoplasmic positivity in cells in tubules.Immunohistochemistry-Paraffin: Spectrin beta 3 Antibody [NBP2-48794]
Immunohistochemistry-Paraffin: Spectrin beta 3 Antibody [NBP2-48794] - Staining of human endometrium shows low expression as expected.Applications for Spectrin beta 3 Antibody
Application
Recommended Usage
Immunohistochemistry
1:50 - 1:200
Immunohistochemistry-Paraffin
1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Formulation, Preparation, and Storage
Purification
Immunogen affinity purified
Formulation
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Concentration
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Background: beta-III Spectrin
Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. Mutations in spectrins are a previously unknown cause of ataxia and neurodegenerative disease that affect membrane proteins involved in glutamate signaling. Spectrin-beta IIIs have been recognized as ataxia disease genes and their mutations cause spinocerebellar ataxia type 5 (SCA5).
Long Name
Spectrin Beta, Non-Erythrocytic 2
Alternate Names
GTRAP41, SCA5, SCAR14, Spectrin beta 3, Spectrin beta III, SPTBN2
Gene Symbol
SPTBN2
Additional beta-III Spectrin Products
Product Documents for Spectrin beta 3 Antibody
Product Specific Notices for Spectrin beta 3 Antibody
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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