SR-BI Antibody (SR37-06)
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-11865
Recombinant Monoclonal Antibody.
Key Product Details
Species Reactivity
Human, Mouse, Rat
Applications
Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot
Label
Unconjugated
Antibody Source
Recombinant Monoclonal Rabbit IgG Clone # SR37-06
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
Recombinant protein (Uniprot#: Q8WTV0)
Clonality
Monoclonal
Host
Rabbit
Isotype
IgG
Theoretical MW
80 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Scientific Data Images for SR-BI Antibody (SR37-06)
Western Blot: SR-BI Antibody (SR37-06) [NBP3-11865]
Western Blot: SR-BI Antibody (SR37-06) [NBP3-11865] - Western blot analysis of SR-BI on different lysates using NBP3-11865 at 1/1,000 dilution. Positive control: Lane 1: Human liver. Lane 2: Mouse liverImmunocytochemistry/ Immunofluorescence: SR-BI Antibody (SR37-06) [NBP3-11865]
Immunocytochemistry/Immunofluorescence: SR-BI Antibody (SR37-06) [NBP3-11865] - Immunocytochemistry staining SR-BI in PC-12 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.Immunohistochemistry-Paraffin: SR-BI Antibody (SR37-06) [NBP3-11865]
Immunohistochemistry-Paraffin: SR-BI Antibody (SR37-06) [NBP3-11865] - Immunohistochemical analysis of paraffin-embedded mouse liver tissue using NBP3-11865. Counter stained with hematoxylin.Applications for SR-BI Antibody (SR37-06)
Application
Recommended Usage
Flow Cytometry
1:50-1:200
Immunocytochemistry/ Immunofluorescence
1:50-1:200
Immunohistochemistry
1:50-1:200
Western Blot
1:1000-5000
Formulation, Preparation, and Storage
Purification
Protein A purified
Formulation
1X TBS (pH7.4), 1% BSA, 40% Glycerol
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at -20C. Avoid freeze-thaw cycles.
Background: SR-BI
At least 5 different human splice variants have been identified with theoretical molecular weights ranging from 60.9 kDa for the canonical sequence to 45 kDa for an N-terminally truncated variant (SR-BII) (3). The extracellular domain of human SR-BI (CLA-1) shares 80%, 80%, 89%, 86% and 84% aa sequence identity with mouse, rat, porcine, rabbit, and bovine SR-BI, respectively. SR-BI is highly glycosylated and removal of N-linked glycosylation reduces lipid transport.
References
1. Linton MF, Tao H, Linton EF, Yancey PG. (2017) SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis. Trends Endocrinol Metab. 28(6):461-472. PMID: 28259375
2. Hoekstra M, Sorci-Thomas M. (2017) Rediscovering scavenger receptor type BI: surprising new roles for the HDL receptor. Curr Opin Lipidol. 28(3):255-260. PMID: 28301373
3. Shen WJ, Asthana S, Kraemer FB, Azhar S. (2018) Scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function.
Long Name
Scavenger Receptor Class B, Member I
Alternate Names
CD36L1, CLA1, HDLQTL6, SCARB1, SR-B1, SRBI
Gene Symbol
SCARB1
Additional SR-BI Products
Product Documents for SR-BI Antibody (SR37-06)
Product Specific Notices for SR-BI Antibody (SR37-06)
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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