SRPRB Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-66584

Novus Biologicals, part of Bio-Techne
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NBP2-66584
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Key Product Details

Species Reactivity

Canine, Chicken

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Sheep IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SRPRB Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to amino acids 246-265 derived from the carboxyl terminal of the canine SRPRB subunit.

Specificity

Antibody will not detect SRPRB protein bound to SRPRA

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Scientific Data Images for SRPRB Antibody

Western Blot: SRPRB Antibody [NBP2-66584]

Western Blot: SRPRB Antibody [NBP2-66584]

Western Blot: SRPRB Antibody [NBP2-66584] - Western blot analysis using SRPRB antibody on 3 (1), 6 (2) and 12 (3) ng of canine microsomal protein.

Applications for SRPRB Antibody

Application
Recommended Usage

Immunohistochemistry

1:10 - 1:500

Western Blot

15 ug/ml
Application Notes
.

Formulation, Preparation, and Storage

Purification

Ammonium sulfate precipitation

Formulation

PBS

Preservative

0.08% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: SRPRB

The receptor for Signal Recognition Particle (SRP) is the site on the endoplasmic reticulum that ribosomes translating secreted and integral membrane proteins are initially targeted to. Once the ribosome-SRP complex arrives at the SRP receptor the protein being translated is transferred to the translocation complex (Sec61) in the ER membrane. The SRP receptor is composed of two subunits SRalpha and SRbeta. The SRalpha subunit is a translocation GTPase peripherally bound to the endoplasmic reticulum by its interaction with SRbeta. SRalpha also binds to the GTPase of SRP (SRP54) and these two proteins appear to function as each others GTPase activating proteins (GAPs). Hydrolysis of GTP by SRalpha and SRP54 is thought to be involved in transfer of the nascent protein to the Sec61 complex in the ER. SRalpha has an apparent molecular weight of 72 kDa. SRbeta is a Type I transmembrane protein that spans the membrane once and contains Ras type GTPase domain. The function of the GTPase in SRbeta is unknown. The membrane spanning domain is at the amino-terminus of SRbeta. The GTPase domain encompasses three quarters of the protein and is carboxyl- of the transmembrane region. SRalpha binds to the GTPase domain of SRbeta. Heterodimerization of SRalpha and SRbeta masks the carboxyl-terminal epitope of SRbeta.

Alternate Names

APMCF1, Protein APMCF1, signal recognition particle receptor subunit beta, signal recognition particle receptor, B subunit, signal recognition particle receptor, beta subunit, SR-beta

Gene Symbol

SRPRB

Additional SRPRB Products

Product Documents for SRPRB Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SRPRB Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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