Stathmin 1 Antibody (RM350)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-23457

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-23457
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM350

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Stathmin/STMN1 Antibodies »

Product Specifications

Immunogen

A peptide corresponding to the C-terminus of human Stathmin 1. (Uniprot#: P16949)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Stathmin 1 Antibody (RM350)

Stathmin 1 Antibody (RM350)

Western Blot: Stathmin 1 Antibody (RM350) [NBP3-23457] -

Western Blot: Stathmin 1 Antibody (RM350) [NBP3-23457] - Western Blot of HeLa cell lysate using Clone RM350) at a 1:5000 dilution.
Stathmin 1 Antibody (RM350)

Immunohistochemistry-Paraffin: Stathmin 1 Antibody (RM350) [NBP3-23457] -

Immunohistochemistry-Paraffin: Stathmin 1 Antibody (RM350) [NBP3-23457] - Immunohistochemical staining of formalin fixed and paraffin embedded human Tonsil tissue section using Clone RM350) at a 1:1000 dilution.

Applications for Stathmin 1 Antibody (RM350)

Application
Recommended Usage

Immunohistochemistry

1:500-1:1000

Western Blot

1:2000-1:5000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Stathmin/STMN1

Stathmin (oncoprotein 18, op18) is a ubiquitous cytosolic phosphoprotein with various regulatory functions in cell proliferation, differentiation signaling, and activation (1). In particular, stathmin is involved in the regulation of tubulin dynamics through inhibition of microtubule formation and/or microtubule depolymerization. Stathmin interacts with soulable tubulins (alpha,beta-tubulin) resulting in the formation of T2S complex which sequesters free tubulin, impeding tubulin formation (2). Stathmin activity is regulated through phosphorylation at Ser16, Ser25, Ser38 and Ser63 by various protein kinases (e.g. MAP-kinase, p34cdc2 kinase), weakening stathmin's affinity to tubulin (3). A mutation on stathmin can lead to excess build up of mitotic spindle and with possible consequence of unregulated cell cycles seen in cancer cells (4). Stathmin is also known as the generic member of a protein family which includes neural proteins SCG10, SCLIP and RB3/RB3/RB3. All members in this family exhibits tubulin binding ability.

Alternate Names

LAP18, Metablastin, OP18, Phosphoprotein p19, Prosolin, SMN, STMN1

Gene Symbol

STMN1

Additional Stathmin/STMN1 Products

Product Documents for Stathmin 1 Antibody (RM350)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Stathmin 1 Antibody (RM350)

[Public Notes]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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