Stathmin 1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-16977

Novus Biologicals, part of Bio-Techne
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NBP3-16977-100ul
NBP3-16977-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (96%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Stathmin/STMN1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: AFELILSPRSKESVPEFPLSPPKKKDL

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Stathmin 1 Antibody

Western Blot: Stathmin 1 Antibody [NBP3-16977]

Western Blot: Stathmin 1 Antibody [NBP3-16977]

Western Blot: Stathmin 1 Antibody [NBP3-16977] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10; Lane 2: RT4; Lane 3: U-251 MG; Lane 4: Human Plasma; Lane 5: Liver; Lane 6: Tonsil
Immunohistochemistry-Paraffin: Stathmin 1 Antibody [NBP3-16977]

Immunohistochemistry-Paraffin: Stathmin 1 Antibody [NBP3-16977]

Immunohistochemistry-Paraffin: Stathmin 1 Antibody [NBP3-16977] - Staining of human cerebral cortex shows high expression.
Immunohistochemistry-Paraffin: Stathmin 1 Antibody [NBP3-16977]

Immunohistochemistry-Paraffin: Stathmin 1 Antibody [NBP3-16977]

Immunohistochemistry-Paraffin: Stathmin 1 Antibody [NBP3-16977] - Staining of human prostate shows low expression as expected.
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Applications for Stathmin 1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Stathmin/STMN1

Stathmin (oncoprotein 18, op18) is a ubiquitous cytosolic phosphoprotein with various regulatory functions in cell proliferation, differentiation signaling, and activation (1). In particular, stathmin is involved in the regulation of tubulin dynamics through inhibition of microtubule formation and/or microtubule depolymerization. Stathmin interacts with soulable tubulins (alpha,beta-tubulin) resulting in the formation of T2S complex which sequesters free tubulin, impeding tubulin formation (2). Stathmin activity is regulated through phosphorylation at Ser16, Ser25, Ser38 and Ser63 by various protein kinases (e.g. MAP-kinase, p34cdc2 kinase), weakening stathmin's affinity to tubulin (3). A mutation on stathmin can lead to excess build up of mitotic spindle and with possible consequence of unregulated cell cycles seen in cancer cells (4). Stathmin is also known as the generic member of a protein family which includes neural proteins SCG10, SCLIP and RB3/RB3/RB3. All members in this family exhibits tubulin binding ability.

Alternate Names

LAP18, Metablastin, OP18, Phosphoprotein p19, Prosolin, SMN, STMN1

Gene Symbol

STMN1

Additional Stathmin/STMN1 Products

Product Documents for Stathmin 1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Stathmin 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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